Interleukin 29

Interferon, lambda 1

Rendering based on PDB 3OG4.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3OG4, 3OG6

Identifiers

Symbols

IFNL1 ; IL-29; IL29

External IDs

OMIM: 607403 HomoloGene: 131189 GeneCards: IFNL1 Gene

Gene ontology
Molecular function	• receptor binding • cytokine activity • interleukin-28 receptor binding
Cellular component	• extracellular region • extracellular space • intracellular • interleukin-28 receptor complex
Biological process	• negative regulation of type 2 immune response • JAK-STAT cascade • negative regulation of cell proliferation • negative regulation of interleukin-13 production • negative regulation of interleukin-5 production • positive regulation of interferon-gamma production • positive regulation of tyrosine phosphorylation of STAT protein • negative regulation of memory T cell differentiation • innate immune response • positive regulation of MHC class I biosynthetic process • negative regulation of T cell differentiation • negative regulation of transcription, DNA-templated • positive regulation of transcription, DNA-templated • positive regulation of JAK-STAT cascade • positive regulation of immune response • defense response to virus
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_172140

n/a

RefSeq (protein)

NP_742152

n/a

Location (UCSC)

Chr 19:
39.3 – 39.3 Mb

n/a

PubMed search

n/a

Interleukin-29 (IL-29) is a protein that in humans is encoded by the IL29 gene that resides on chromosome 19.^[1]^[2]

IL-29 is a member of the helical cytokine family and is a type III interferon.^[3] It is also known as IFNλ1 and is highly similar in amino acid sequence to the IL-28, the other type III interferon. IL-29 plays an important role in host defenses against microbes and its gene is highly upregulated in cells infected with viruses. IL29 is not present in the mouse genome.

References

↑ "Entrez Gene: interleukin 29 (interferon".
↑ Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, Kuestner R, Garrigues U, Birks C, Roraback J, Ostrander C, Dong D, Shin J, Presnell S, Fox B, Haldeman B, Cooper E, Taft D, Gilbert T, Grant FJ, Tackett M, Krivan W, McKnight G, Clegg C, Foster D, Klucher KM (January 2003). "IL-28, IL-29 and their class II cytokine receptor IL-28R". Nat. Immunol. 4 (1): 63–8. doi:10.1038/ni873. PMID 12469119.
↑ Vilcek J (January 2003). "Novel interferons". Nat. Immunol. 4 (1): 8–9. doi:10.1038/ni0103-8. PMID 12496969.

Pagliaccetti NE, Eduardo R, Kleinstein SH, et al. (2008). "Interleukin-29 functions cooperatively with interferon to induce antiviral gene expression and inhibit hepatitis C virus replication". J. Biol. Chem. 283 (44): 30079–89. doi:10.1074/jbc.M804296200. PMC 2662072. PMID 18757365.
Li MC, Wang HY, Wang HY, et al. (2006). "Liposome-mediated IL-28 and IL-29 expression in A549 cells and anti-viral effect of IL-28 and IL-29 on WISH cells". Acta Pharmacol. Sin. 27 (4): 453–9. doi:10.1111/j.1745-7254.2006.00292.x. PMID 16539846.
Megjugorac NJ, Gallagher GE, Gallagher G (2009). "Modulation of human plasmacytoid DC function by IFN-lambda1 (IL-29)". J. Leukoc. Biol. 86 (6): 1359–63. doi:10.1189/jlb.0509347. PMID 19759281.
UzÃ© G, Monneron D (2007). "IL-28 and IL-29: newcomers to the interferon family". Biochimie 89 (6–7): 729–34. doi:10.1016/j.biochi.2007.01.008. PMID 17367910.
Hou W, Wang X, Ye L, et al. (2009). "Lambda interferon inhibits human immunodeficiency virus type 1 infection of macrophages". J. Virol. 83 (8): 3834–42. doi:10.1128/JVI.01773-08. PMC 2663280. PMID 19193806.
Magracheva E, Pletnev S, Kotenko S, et al. (2010). "Purification, crystallization and preliminary crystallographic studies of the complex of interferon-lambda1 with its receptor". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 66 (Pt 1): 61–3. doi:10.1107/S1744309109048817. PMC 2805539. PMID 20057073.
Stoltz M, KlingstrÃ¶m J (2010). "Alpha/beta interferon (IFN-alpha/beta)-independent induction of IFN-lambda1 (interleukin-29) in response to Hantaan virus infection". J. Virol. 84 (18): 9140–8. doi:10.1128/JVI.00717-10. PMC 2937636. PMID 20592090.
Brand S, Beigel F, Olszak T, et al. (2005). "IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression". Am. J. Physiol. Gastrointest. Liver Physiol. 289 (5): G960–8. doi:10.1152/ajpgi.00126.2005. PMID 16051921.
Pekarek V, Srinivas S, Eskdale J, Gallagher G (2007). "Interferon lambda-1 (IFN-lambda1/IL-29) induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner". Genes Immun. 8 (2): 177–80. doi:10.1038/sj.gene.6364372. PMID 17252004.
Li M, Liu X, Zhou Y, Su SB (2009). "Interferon-lambdas: the modulators of antivirus, antitumor, and immune responses". J. Leukoc. Biol. 86 (1): 23–32. doi:10.1189/jlb.1208761. PMID 19304895.
Jordan WJ, Eskdale J, Boniotto M, et al. (2007). "Modulation of the human cytokine response by interferon lambda-1 (IFN-lambda1/IL-29)". Genes Immun. 8 (1): 13–20. doi:10.1038/sj.gene.6364348. PMID 17082759.
Wang J, Oberley-Deegan R, Wang S, et al. (2009). "Differentiated human alveolar type II cells secrete antiviral IL-29 (IFN-lambda 1) in response to influenza A infection". J. Immunol. 182 (3): 1296–304. doi:10.4049/jimmunol.182.3.1296. PMID 19155475.
Lasfar A, Lewis-Antes A, Smirnov SV, et al. (2006). "Characterization of the mouse IFN-lambda ligand-receptor system: IFN-lambdas exhibit antitumor activity against B16 melanoma". Cancer Res. 66 (8): 4468–77. doi:10.1158/0008-5472.CAN-05-3653. PMID 16618774.
Osterlund P, Veckman V, SirÃ©n J; et al. (2005). "Gene expression and antiviral activity of alpha/beta interferons and interleukin-29 in virus-infected human myeloid dendritic cells". J. Virol. 79 (15): 9608–17. doi:10.1128/JVI.79.15.9608-9617.2005. PMC 1181545. PMID 16014923.
Maher SG, Sheikh F, Scarzello AJ, et al. (2008). "IFNalpha and IFNlambda differ in their antiproliferative effects and duration of JAK/STAT signaling activity". Cancer Biol. Ther. 7 (7): 1109–15. doi:10.4161/cbt.7.7.6192. PMC 2435218. PMID 18698163.
Mennechet FJ, UzÃ© G (2006). "Interferon-lambda-treated dendritic cells specifically induce proliferation of FOXP3-expressing suppressor T cells". Blood 107 (11): 4417–23. doi:10.1182/blood-2005-10-4129. PMID 16478884.
Wolk K, Witte K, Witte E, et al. (2008). "Maturing dendritic cells are an important source of IL-29 and IL-20 that may cooperatively increase the innate immunity of keratinocytes". J. Leukoc. Biol. 83 (5): 1181–93. doi:10.1189/jlb.0807525. PMID 18281438.
Novak AJ, Grote DM, Ziesmer SC, et al. (2008). "A role for IFN-lambda1 in multiple myeloma B cell growth". Leukemia 22 (12): 2240–6. doi:10.1038/leu.2008.263. PMC 2771776. PMID 18830264.
Witte K, Gruetz G, Volk HD, et al. (2009). "Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines". Genes Immun. 10 (8): 702–14. doi:10.1038/gene.2009.72. PMID 19798076.
Rauch A, Kutalik Z, Descombes P, et al. (2010). "Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study". Gastroenterology 138 (4): 1338–45, 1345.e1–7. doi:10.1053/j.gastro.2009.12.056. PMID 20060832.

Cell signaling: cytokines

By family

Chemokine

CCL	CCL1 CCL2/MCP1 CCL3/MIP1α CCL4/MIP1β CCL5/RANTES CCL6 CCL7 CCL8 CCL9 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18/PARC/DCCK1/AMAC1/MIP4 CCL19 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28

CXCL	CXCL1/KC CXCL2 CXCL3 CXCL4 CXCL5 CXCL6 CXCL7 CXCL8/IL8 CXCL9 CXCL10 CXCL11 CXCL12 CXCL13 CXCL14 CXCL15 CXCL16 CXCL17

CX3CL	CX3CL1

XCL	XCL1 XCL2

TNF

Interleukin

Type I
(grouped by
receptor
subunit)

γ chain	IL2/IL15 IL4/IL13 IL7 IL9 IL21

β chain	IL3 IL5 GMCSF

IL6 like/gp130	IL6 IL11 IL27 IL30 IL31 +non IL OSM LIF CNTF CTF1

IL12 family/IL12RB1	IL12 IL23 IL27 IL35

Other	IL14 IL16 IL32 IL34

Type II

IL10 family

IL10/IL22
IL19
IL20
IL24
IL26
Interferon type III
- IL28/IFNL2+3
- IL29/IFNL1

Interferon

I	IFNA1 IFNA2 IFNA4 IFNA5 IFNA6 IFNA7 IFNA8 IFNA10 IFNA13 IFNA14 IFNA16 IFNA17 IFNA21 IFNB1 IFNK IFNW1

II	IFNG

Ig superfamily

IL17 family

IL17/IL25 (IL17A)

Other

By function/
cell

proinflammatory cytokine
- IL1
- TNFA

Monokine
Lymphokine
- T_h1
  - IFNγ
  - TNFβ
- T_h2
  - IL4
  - IL5
  - IL6
  - IL10
  - IL13

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Interleukin 29

References

Further reading