Ink4

INK4 is a tumour suppressor protein. It is associated with several genes, including p16INK4a and p14ARF, and with several other proteins, like HRAS.[1] Lack of this protein has been associated with several types of cancer, including bladder and melanoma. The 'INK4' label is given to three proteins: INK4A and INK4B. These proteins act to inhibit cdk4 and cdk6 upon binding, causing the arrest of the cell cycle in G1.[2]

References

  1. ↑ Oncogenic activity of Cdc6 through repression of the INK4/ARF locus : Nature
  2. ↑ INK4 Tumor Suppressor Proteins in the CDK4


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