Idrocilamide
 | |
| Systematic (IUPAC) name | |
|---|---|
|
N-(2-Hydroxyethyl)-3-phenyl-2-propenamide | |
| Clinical data | |
| Trade names | Talval, Srilane, Relaxnova, Brolitène |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Topical |
| Identifiers | |
| CAS Number |
6961-46-2  |
| ATC code | M02AX05 |
| PubChem | CID 1550874 |
| ChemSpider |
1267352  |
| UNII |
6C816LUB1O |
| ChEMBL |
CHEMBL102358 |
| Chemical data | |
| Formula | C11H13NO2 |
| Molar mass | 191.226 g/mol |
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| (what is this?) (verify) | |
Idrocilamide (trade names Talval, Srilane, Relaxnova, Brolitène[1]) is a medication with skeletal muscle relaxant[2] and anti-inflammatory actions[3] used as a topical cream to treat lumbago and other kinds of muscular pain;[4] it is available on prescription or over-the-counter in France and various other countries.[1]
Interactions
Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.[5][6]
References
- 1 2 Drugs.com: International Drug Names
- ↑ Bouron, A.; Rivet, M.; Nasri-Sebdani, M.; Guillemain, J.; Durbin, P.; Guerrier, D.; Raymond, G. (1990). "The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers". Canadian journal of physiology and pharmacology 68 (12): 1503–1509. doi:10.1139/y90-228. PMID 2085796.
- ↑ Bannwarth B, Le Huec JC, Vinçon G, et al. (December 1993). "[Tissue and systemic diffusion of idrocilamide after cutaneous administration]". Rev Rhum Ed Fr (in French) 60 (12): 932–6. PMID 8012322.
- ↑ Stehman, M.; Lehert, P. (1990). "Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago". Acta Belgica. Medica physica : organe officiel de la Societe royale belge de medecine physique et de rehabilitation 13 (1): 29–32. PMID 2140002.
- ↑ Carrillo JA, Benitez J (August 2000). "Clinically significant pharmacokinetic interactions between dietary caffeine and medications". Clin Pharmacokinet 39 (2): 127–53. doi:10.2165/00003088-200039020-00004. PMID 10976659.
- ↑ Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC (January 1980). "Inhibition by idrocilamide of the disposition of caffeine". Eur. J. Clin. Pharmacol. 17 (1): 37–43. doi:10.1007/bf00561675. PMID 7371698.
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