IRS4
| Insulin receptor substrate 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | IRS4 ; IRS-4; PY160 | ||||||||||||
| External IDs | OMIM: 300904 MGI: 1338009 HomoloGene: 136777 GeneCards: IRS4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 8471 | 16370 | |||||||||||
| Ensembl | ENSG00000133124 | ENSMUSG00000054667 | |||||||||||
| UniProt | O14654 | Q9Z0Y7 | |||||||||||
| RefSeq (mRNA) | NM_003604 | NM_010572 | |||||||||||
| RefSeq (protein) | NP_003595 | NP_034702 | |||||||||||
| Location (UCSC) |
Chr X: 108.73 – 108.74 Mb |
Chr X: 141.71 – 141.73 Mb | |||||||||||
| PubMed search | |||||||||||||
Insulin receptor substrate 4 is a protein that in humans is encoded by the IRS4 gene.[1][2][3]
IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.[3]
Interactions
IRS4 has been shown to interact with CRK[4][5] and NISCH.[6]
References
- ↑ Lavan BE, Fantin VR, Chang ET, Lane WS, Keller SR, Lienhard GE (Sep 1997). "A novel 160-kDa phosphotyrosine protein in insulin-treated embryonic kidney cells is a new member of the insulin receptor substrate family". J Biol Chem 272 (34): 21403–7. doi:10.1074/jbc.272.34.21403. PMID 9261155.
- ↑ Fantin VR, Sparling JD, Slot JW, Keller SR, Lienhard GE, Lavan BE (May 1998). "Characterization of insulin receptor substrate 4 in human embryonic kidney 293 cells". J Biol Chem 273 (17): 10726–32. doi:10.1074/jbc.273.17.10726. PMID 9553137.
- 1 2 "Entrez Gene: IRS4 insulin receptor substrate 4".
- ↑ Karas, M; Koval A P; Zick Y; LeRoith D (May 2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II". Endocrinology (United States) 142 (5): 1835–40. doi:10.1210/en.142.5.1835. ISSN 0013-7227. PMID 11316748.
- ↑ Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction". J. Biol. Chem. (UNITED STATES) 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. ISSN 0021-9258. PMID 9614078.
- ↑ Sano, Hiroyuki; Liu Simon C H; Lane William S; Piletz John E; Lienhard Gustav E (May 2002). "Insulin receptor substrate 4 associates with the protein IRAS". J. Biol. Chem. (United States) 277 (22): 19439–47. doi:10.1074/jbc.M111838200. ISSN 0021-9258. PMID 11912194.
Further reading
- White MF (1999). "The IRS-signalling system: a network of docking proteins that mediate insulin action.". Mol. Cell. Biochem. 182 (1–2): 3–11. doi:10.1023/A:1006806722619. PMID 9609109.
- Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.". J. Biol. Chem. 273 (24): 14780–7. doi:10.1074/jbc.273.24.14780. PMID 9614078.
- Uchida T, Myers MG, White MF (2000). "IRS-4 mediates protein kinase B signaling during insulin stimulation without promoting antiapoptosis.". Mol. Cell. Biol. 20 (1): 126–38. doi:10.1128/MCB.20.1.126-138.2000. PMC 85068. PMID 10594015.
- Karas M, Koval AP, Zick Y, LeRoith D (2001). "The insulin-like growth factor I receptor-induced interaction of insulin receptor substrate-4 and Crk-II.". Endocrinology 142 (5): 1835–40. doi:10.1210/en.142.5.1835. PMID 11316748.
- Sano H, Liu SC, Lane WS, et al. (2002). "Insulin receptor substrate 4 associates with the protein IRAS.". J. Biol. Chem. 277 (22): 19439–47. doi:10.1074/jbc.M111838200. PMID 11912194.
- Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMC 133908. PMID 12052866.
- Schreyer S, Ledwig D, Rakatzi I, et al. (2003). "Insulin receptor substrate-4 is expressed in muscle tissue without acting as a substrate for the insulin receptor.". Endocrinology 144 (4): 1211–8. doi:10.1210/en.2002-220723. PMID 12639902.
- Escribano O, Fernández-Moreno MD, Zueco JA, et al. (2003). "Insulin receptor substrate-4 signaling in quiescent rat hepatocytes and in regenerating rat liver.". Hepatology 37 (6): 1461–9. doi:10.1053/jhep.2003.50245. PMID 12774026.
- Yen HW, Jakimiuk AJ, Munir I, Magoffin DA (2005). "Selective alterations in insulin receptor substrates-1, -2 and -4 in theca but not granulosa cells from polycystic ovaries.". Mol. Hum. Reprod. 10 (7): 473–9. doi:10.1093/molehr/gah066. PMID 15155816.
- Hinsby AM, Olsen JV, Mann M (2004). "Tyrosine phosphoproteomics of fibroblast growth factor signaling: a role for insulin receptor substrate-4.". J. Biol. Chem. 279 (45): 46438–47. doi:10.1074/jbc.M404537200. PMID 15316024.
- Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
- Mihindukulasuriya KA, Zhou G, Qin J, Tan TH (2004). "Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.". J. Biol. Chem. 279 (45): 46588–94. doi:10.1074/jbc.M408067200. PMID 15331607.
- Qiu H, Zappacosta F, Su W, et al. (2005). "Interaction between Brk kinase and insulin receptor substrate-4.". Oncogene 24 (36): 5656–64. doi:10.1038/sj.onc.1208721. PMID 15870689.
- Cuevas EP, Escribano O, Chiloeches A, et al. (2007). "Role of insulin receptor substrate-4 in IGF-I-stimulated HEPG2 proliferation.". J. Hepatol. 46 (6): 1089–98. doi:10.1016/j.jhep.2007.01.031. PMID 17408801.
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