Mitochondrial antiviral-signaling protein

Mitochondrial antiviral signaling protein

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2VGQ, 3J6C, 3J6J, 3RC5, 4P4H

Identifiers

Symbols

MAVS ; CARDIF; IPS-1; IPS1; VISA

External IDs

OMIM: 609676 MGI: 2444773 HomoloGene: 17004 GeneCards: MAVS Gene

Gene ontology
Molecular function	• signal transducer activity • protein binding • protein kinase binding • CARD domain binding
Cellular component	• mitochondrion • mitochondrial outer membrane • peroxisomal membrane • integral component of membrane • mitochondrial membrane
Biological process	• positive regulation of protein phosphorylation • activation of innate immune response • positive regulation of defense response to virus by host • signal transduction • viral process • negative regulation of type I interferon production • positive regulation of interferon-alpha production • positive regulation of interferon-beta production • positive regulation of interleukin-8 production • positive regulation of tumor necrosis factor production • positive regulation of protein import into nucleus, translocation • RIG-I signaling pathway • defense response to bacterium • positive regulation of transcription factor import into nucleus • positive regulation of I-kappaB kinase/NF-kappaB signaling • negative regulation of viral genome replication • innate immune response • positive regulation of transcription from RNA polymerase II promoter • positive regulation of sequence-specific DNA binding transcription factor activity • defense response to virus • positive regulation of type I interferon-mediated signaling pathway • cellular response to exogenous dsRNA • positive regulation of chemokine (C-C motif) ligand 5 production • positive regulation of IP-10 production • regulation of peroxisome organization
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 20:
3.85 – 3.88 Mb

Chr 2:
131.23 – 131.25 Mb

PubMed search

Mitochondrial antiviral-signaling protein (MAVS) is a protein that in humans is encoded by the MAVS gene.^[1]^[2]^[3] The protein is also known by the names VISA (virus-induced signaling adapter), IPS-1 and Cardif. Aggregated MAVS forms protease resistant prion-like aggregates that activate IRF3 dimerization.^[4]

Function

Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic RNA helicases MDA5 and RIGI. These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK) and IKKB (IKBKB; MIM 603258), which activate NFKB, or TBK1 and IKBKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNβ (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound MAVS.^[3]^[5]

References

↑ Seth RB, Sun L, Ea CK, Chen ZJ (Sep 2005). "Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3". Cell 122 (5): 669–82. doi:10.1016/j.cell.2005.08.012. PMID 16125763.
↑ Xu LG, Wang YY, Han KJ, Li LY, Zhai Z, Shu HB (Sep 2005). "VISA is an adapter protein required for virus-triggered IFN-beta signaling". Mol Cell 19 (6): 727–40. doi:10.1016/j.molcel.2005.08.014. PMID 16153868.
1 2 "Entrez Gene: VISA virus-induced signaling adapter".
↑ Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (Aug 5, 2011). "MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response.". Cell 146 (3): 448–61. doi:10.1016/j.cell.2011.06.041. PMC 3179916. PMID 21782231.
↑ Sen GC, Sarkar SN (2005). "Hitching RIG to action". Nat. Immunol. 6 (11): 1074–6. doi:10.1038/ni1105-1074. PMID 16239922.

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Mitochondrial antiviral-signaling protein

Function

References

Further reading