IGHM

Immunoglobulin heavy constant mu

Available structures

Human UniProt search: PDBe, RCSB

List of PDB id codes
2AGJ

Identifiers

Symbols

IGHM ; AGM1; MU; VH

External IDs

OMIM: 147020 GeneCards: IGHM Gene

Gene ontology
Molecular function	• single-stranded DNA binding • antigen binding • protein binding • phosphatidylcholine binding • immunoglobulin receptor binding • peptidoglycan binding
Cellular component	• extracellular space • plasma membrane • cell surface • integral component of membrane • extracellular exosome • pentameric IgM immunoglobulin complex • hexameric IgM immunoglobulin complex • blood microparticle
Biological process	• adaptive immune response • antibacterial humoral response • innate immune response • defense response to Gram-negative bacterium
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

n/a

PubMed search

n/a

Ig mu chain C region is a protein that in humans is encoded by the IGHM gene.^[1]^[2]

It is associated with agammaglobulinemia-1.

References

↑ Friedlander RM, Nussenzweig MC, Leder P (Sep 1990). "Complete nucleotide sequence of the membrane form of the human IgM heavy chain". Nucleic Acids Res 18 (14): 4278. doi:10.1093/nar/18.14.4278. PMC 331217. PMID 2115996.
↑ "Entrez Gene: IGHM immunoglobulin heavy constant mu".

Kristensen T, Lopez R, Prydz H (1992). "An estimate of the sequencing error frequency in the DNA sequence databases.". DNA Seq. 2 (6): 343–6. doi:10.3109/10425179209020815. PMID 1446073.
Frutiger S, Hughes GJ, Paquet N, et al. (1993). "Disulfide bond assignment in human J chain and its covalent pairing with immunoglobulin M.". Biochemistry 31 (50): 12643–7. doi:10.1021/bi00165a014. PMID 1472500.
Neale GA, Kitchingman GR (1991). "mRNA transcripts initiating within the human immunoglobulin mu heavy chain enhancer region contain a non-translatable exon and are extremely heterogeneous at the 5' end.". Nucleic Acids Res. 19 (9): 2427–33. doi:10.1093/nar/19.9.2427. PMC 329453. PMID 1904154.
Tsubata T, Reth M (1990). "The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface.". J. Exp. Med. 172 (3): 973–6. doi:10.1084/jem.172.3.973. PMC 2188549. PMID 2117639.
Dorai H, Gillies SD (1989). "The complete nucleotide sequence of a human immunoglobulin genomic C mu gene.". Nucleic Acids Res. 17 (15): 6412. doi:10.1093/nar/17.15.6412. PMC 318311. PMID 2505237.
Pollok BA, Anker R, Eldridge P, et al. (1988). "Molecular basis of the cell-surface expression of immunoglobulin mu chain without light chain in human B lymphocytes.". Proc. Natl. Acad. Sci. U.S.A. 84 (24): 9199–203. doi:10.1073/pnas.84.24.9199. PMC 299720. PMID 3122216.
Putnam FW, Florent G, Paul C, et al. (1973). "Complete amino acid sequence of the Mu heavy chain of a human IgM immunoglobulin.". Science 182 (4109): 287–91. doi:10.1126/science.182.4109.287. PMID 4742735.
Watanabe S, Barnikol HU, Horn J, et al. (1975). "[The primary structure of a monoclonal IgM-immunoglobulin (macroglobulin Gal.), II: the amino acid sequence of the H-chain (mu-type), subgroup H III. Architecture of the complete IgM-molecule (author's transl)]". Hoppe-Seyler's Z. Physiol. Chem. 354 (10-11): 1505–9. PMID 4803843.
Mihaesco E, Barnikol-Watanabe S, Barnikol HU, et al. (1981). "The primary structure of the constant part of mu-chain-disease protein BOT.". Eur. J. Biochem. 111 (1): 275–86. doi:10.1111/j.1432-1033.1980.tb06103.x. PMID 6777162.
Dolby TW, Devuono J, Croce CM (1981). "Cloning and partial nucleotide sequence of human immunoglobulin mu chain cDNA from B cells and mouse-human hybridomas.". Proc. Natl. Acad. Sci. U.S.A. 77 (10): 6027–31. doi:10.1073/pnas.77.10.6027. PMC 350206. PMID 6777778.
Rabbitts TH, Forster A, Milstein CP (1982). "Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences.". Nucleic Acids Res. 9 (18): 4509–24. doi:10.1093/nar/9.18.4509. PMC 327454. PMID 6795593.
Ohnishi K, Takemori T (1994). "Molecular components and assembly of mu.surrogate light chain complexes in pre-B cell lines.". J. Biol. Chem. 269 (45): 28347–53. PMID 7961773.
Harindranath N, Donadel G, Sigounas G, Notkins AL (1993). "Comparison of complete nucleotide sequence of the human IgM heavy chain constant region of polyreactive and monoreactive antibodies.". Mol. Immunol. 30 (1): 111–2. doi:10.1016/0161-5890(93)90434-D. PMID 8417370.
Donohoe ME, Blomberg BB (1997). "The 14.1 surrogate light chain promoter has lineage- and stage-restricted activity.". J. Immunol. 158 (4): 1681–91. PMID 9029104.
Li Q, Santini R, Rosenspire AR (1998). "Glycosylated extracellular domains of membrane immunoglobulin M contribute to its association with mb-1/B29 gene products and the B cell receptor complex.". Immunol. Invest. 27 (1-2): 57–72. doi:10.3109/08820139809070890. PMID 9561918.
Paterson T, Innes J, McMillan L, et al. (1998). "Variation in IgG1 heavy chain allotype does not contribute to differences in biological activity of two human anti-Rhesus (D) monoclonal antibodies.". Immunotechnology 4 (1): 37–47. doi:10.1016/S1380-2933(98)00005-0. PMID 9661813.
Fang T, Smith BP, Roman CA (2001). "Conventional and surrogate light chains differentially regulate Ig mu and Dmu heavy chain maturation and surface expression.". J. Immunol. 167 (7): 3846–57. doi:10.4049/jimmunol.167.7.3846. PMID 11564802.
Taylor BJ, Pittman JA, Seeberger K, et al. (2002). "Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.". Clin. Cancer Res. 8 (2): 502–13. PMID 11839670.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

Antibodies

Antibodies	Light chain IGK@ IGL@ surrogate IGLL1 Heavy chain IGH@ IGHM IgA IgD IgE IgG IgM IgY Heavy-chain antibody/IgNAR

see also disorders of globin and globulin proteins

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IGHM

References

Further reading