IGHE

Immunoglobulin heavy constant epsilon

Available structures

Human UniProt search: PDBe, RCSB

List of PDB id codes
1F6A, 1FP5, 1G84, 1O0V, 2WQR, 2Y7Q, 3H9Y, 3H9Z, 3HA0, 4EZM, 4GRG, 4GT7

Identifiers

Symbols

IGHE ; IgE

External IDs

OMIM: 147180 IUPHAR: 2741 GeneCards: IGHE Gene

Gene ontology
Molecular function	• antigen binding
Cellular component	• extracellular region
Biological process	• immune response • Fc-epsilon receptor signaling pathway • innate immune response
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

n/a

RefSeq (protein)

n/a

Location (UCSC)

n/a

PubMed search

n/a

Ig epsilon chain C region is a protein that in humans is encoded by the IGHE gene.^[1]

References

↑ "Entrez Gene: IGHE immunoglobulin heavy constant epsilon".

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Flanagan JG, Rabbitts TH (1984). "The sequence of a human immunoglobulin epsilon heavy chain constant region gene, and evidence for three non-allelic genes". The EMBO Journal 1 (5): 655–60. PMC 553102. PMID 6234164.
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Seno M, Kurokawa T, Ono Y, Onda H, Sasada R, Igarashi K, Kikuchi M, Sugino Y, Nishida Y, Honjo T (Feb 1983). "Molecular cloning and nucleotide sequencing of human immunoglobulin epsilon chain cDNA". Nucleic Acids Research 11 (3): 719–26. doi:10.1093/nar/11.3.719. PMC 325748. PMID 6300763.
Ueda S, Nakai S, Nishida Y, Hisajima H, Honjo T (1984). "Long terminal repeat-like elements flank a human immunoglobulin epsilon pseudogene that lacks introns". The EMBO Journal 1 (12): 1539–44. PMC 553248. PMID 6327276.
Hisajima H, Nishida Y, Nakai S, Takahashi N, Ueda S, Honjo T (May 1983). "Structure of the human immunoglobulin C epsilon 2 gene, a truncated pseudogene: implications for its evolutionary origin". Proceedings of the National Academy of Sciences of the United States of America 80 (10): 2995–9. doi:10.1073/pnas.80.10.2995. PMC 393960. PMID 6407005.
Flanagan JG, Lefranc MP, Rabbitts TH (Mar 1984). "Mechanisms of divergence and convergence of the human immunoglobulin alpha 1 and alpha 2 constant region gene sequences". Cell 36 (3): 681–8. doi:10.1016/0092-8674(84)90348-9. PMID 6421489.
Ellison J, Hood L (Mar 1982). "Linkage and sequence homology of two human immunoglobulin gamma heavy chain constant region genes". Proceedings of the National Academy of Sciences of the United States of America 79 (6): 1984–8. doi:10.1073/pnas.79.6.1984. PMC 346106. PMID 6804948.
Kenten JH, Molgaard HV, Houghton M, Derbyshire RB, Viney J, Bell LO, Gould HJ (Nov 1982). "Cloning and sequence determination of the gene for the human immunoglobulin epsilon chain expressed in a myeloma cell line". Proceedings of the National Academy of Sciences of the United States of America 79 (21): 6661–5. doi:10.1073/pnas.79.21.6661. PMC 347188. PMID 6815656.
Valenta R, Natter S, Seiberler S, Wichlas S, Maurer D, Hess M, Pavelka M, Grote M, Ferreira F, Szepfalusi Z, Valent P, Stingl G (Dec 1998). "Molecular characterization of an autoallergen, Hom s 1, identified by serum IgE from atopic dermatitis patients". The Journal of Investigative Dermatology 111 (6): 1178–83. doi:10.1046/j.1523-1747.1998.00413.x. PMID 9856836.
Anderson GG, Leaves NI, Bhattacharyya S, Zhang Y, Walshe V, Broxholme J, Abecasis G, Levy E, Zimmer M, Cox R, Cookson WO (Apr 2002). "Positive association to IgE levels and a physical map of the 13q14 atopy locus". European Journal of Human Genetics 10 (4): 266–70. doi:10.1038/sj.ejhg.5200801. PMID 12032735.
Cocco RR, Järvinen KM, Sampson HA, Beyer K (Aug 2003). "Mutational analysis of major, sequential IgE-binding epitopes in alpha s1-casein, a major cow's milk allergen". The Journal of Allergy and Clinical Immunology 112 (2): 433–7. doi:10.1067/mai.2003.1617. PMID 12897753.
Hajoui O, Janani R, Tulic M, Joubert P, Ronis T, Hamid Q, Zheng H, Mazer BD (Sep 2004). "Synthesis of IL-13 by human B lymphocytes: regulation and role in IgE production". The Journal of Allergy and Clinical Immunology 114 (3): 657–63. doi:10.1016/j.jaci.2004.05.034. PMID 15356573.
Takhar P, Smurthwaite L, Coker HA, Fear DJ, Banfield GK, Carr VA, Durham SR, Gould HJ (Apr 2005). "Allergen drives class switching to IgE in the nasal mucosa in allergic rhinitis". Journal of Immunology 174 (8): 5024–32. doi:10.4049/jimmunol.174.8.5024. PMID 15814733.
Batra J, Rajpoot R, Ahluwalia J, Devarapu SK, Sharma SK, Dinda AK, Ghosh B (Jun 2007). "A hexanucleotide repeat upstream of eotaxin gene promoter is associated with asthma, serum total IgE and plasma eotaxin levels". Journal of Medical Genetics 44 (6): 397–403. doi:10.1136/jmg.2006.046607. PMC 2740889. PMID 17220216.

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IGHE

References

Further reading