Hydrocodone/ibuprofen
| Combination of | |
|---|---|
| Hydrocodone | Opioid analgesic |
| Ibuprofen | Non-steroidal anti-inflammatory drug |
| Clinical data | |
| Trade names | Ibudone, Reprexain, Vicoprofen |
| AHFS/Drugs.com | Consumer Drug Information |
| MedlinePlus | a601006 |
| Licence data | US FDA:link |
| Pregnancy category |
|
| Legal status |
|
| Dependence liability | Moderate |
| Routes of administration | Oral |
| Pharmacokinetic data | |
| Bioavailability | >80% |
| Metabolism | for hydrocodone: hepatic, CYP3A4; for ibuprofen: hepatic, CYP2C9 |
| Biological half-life | for hydrocodone: 228-294 mins (3.8-4.9 hrs); for ibuprofen: 108-120 mins (1.8-2 hrs) |
| Excretion | for hydrocodone: urinary; for ibuprofen: urine primarily (<1% unchanged) |
| Identifiers | |
| CAS Number |
615580-69-3  |
| ATC code | M01AE51 |
| PubChem | SID 7849213 |
| KEGG |
D02152 |
| (verify) | |
The drug combination hydrocodone/ibuprofen (INNs, trade name Vicoprofen) is an analgesic medication used in short-term therapy to relieve severe pain.[1] Hydrocodone is used in form of the bitartrate. This combination avoids some of the liver toxicity which may occur with hydrocodone/paracetamol combinations such as Vicodin, but still presents significant dangers in hydrocodone overdose, namely respiratory depression.
Generic hydrocodone/ibuprofen 7.5/200 mg
See also
- Hydrocodone/paracetamol
- Oxycodone/paracetamol
- Oxycodone/aspirin
- Oxycodone/naloxone
- Morphine/naltrexone
- Fentanyl/fluanisone
References
- ↑ Drugs.com: Vicoprofen
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