Host cell factor C1

Host cell factor C1
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4GO6​, 4N39​, 4N3A​, 4N3B​, 4N3C​
Identifiers
Symbols	HCFC1 ; CFF; HCF; HCF-1; HCF1; HFC1; MRX3; PPP1R89; VCAF
External IDs	OMIM: 300019 MGI: 105942 HomoloGene: 3898 GeneCards: HCFC1 Gene
Gene ontology Molecular function • transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding • chromatin binding • transcription factor activity, sequence-specific DNA binding • transcription coactivator activity • protein binding • identical protein binding • histone acetyltransferase activity (H4-K5 specific) • histone acetyltransferase activity (H4-K8 specific) • histone acetyltransferase activity (H4-K16 specific) Cellular component • histone acetyltransferase complex • nucleus • nucleoplasm • Ada2/Gcn5/Ada3 transcription activator complex • cytoplasm • mitochondrion • membrane • axon • dendrite • neuronal cell body • Set1C/COMPASS complex • SAGA-type complex • MLL5-L complex • MLL1 complex Biological process • negative regulation of transcription from RNA polymerase II promoter • chromatin organization • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • organelle organization • mitochondrion organization • cell cycle • positive regulation of gene expression • release from viral latency • regulation of protein complex assembly • histone H4-K5 acetylation • histone H4-K8 acetylation • histone H4-K16 acetylation • positive regulation of cell cycle • positive regulation of transcription from RNA polymerase II promoter • protein stabilization • cellular response to organic cyclic compound Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3054	15161
Ensembl	ENSG00000172534	ENSMUSG00000031386
UniProt	P51610	Q61191
RefSeq (mRNA)	NM_005334	NM_008224
RefSeq (protein)	NP_005325	NP_032250
Location (UCSC)	Chr X: 153.95 – 153.97 Mb	Chr X: 73.94 – 73.97 Mb
PubMed search

Host cell factor 1 (HCFC1, HCF1, or HCF-1), also known as VP16-accessory protein,^[1] is a protein that in humans is encoded by the HCFC1 gene.^[2][3]

Structure

HCF1 is a member of the highly conserved host cell factor family and encodes a protein with five Kelch repeats, a fibronectin-like motif, and six HCF repeats, each of which contains a highly specific cleavage signal. This nuclear transcription coregulator is proteolytically cleaved at one or more of the six possible sites, resulting in the creation of an N-terminal chain and the corresponding C-terminal chain. The final form of this protein consists of noncovalently bound N- and C-terminal chains which interact through electrostatic forces.

Function

HCF1 is involved in control of the cell cycle as well as having regulatory roles in a multitude of processes related to transcription. Additionally, work in model organisms point to HCF1 as being a putative longevity determinant.^[4] Alternatively spliced variants that encode different protein isoforms have been described; however, not all variants have been fully characterized.^[3]

Mutations in this gene have been linked to disorders of the cobalamine metabolism.^[5]

Interactions

Host cell factor C1 has been shown to interact with:

References

Further reading