Hepatoma-derived growth factor

PDB rendering based on 1ri0.

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
1RI0, 2NLU

Identifiers

Symbols

HDGF ; HMG1L2

External IDs

OMIM: 600339 MGI: 1194494 HomoloGene: 3306 GeneCards: HDGF Gene

Gene ontology
Molecular function	• nucleotide binding • RNA polymerase II transcription corepressor activity • transcription corepressor binding • DNA binding • growth factor activity • heparin binding • poly(A) RNA binding
Cellular component	• extracellular space • nucleoplasm • cytoplasm • transcriptional repressor complex
Biological process	• negative regulation of transcription from RNA polymerase II promoter • transcription, DNA-templated • signal transduction • cell proliferation • endoplasmic reticulum unfolded protein response • IRE1-mediated unfolded protein response • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
156.74 – 156.77 Mb

Chr 3:
87.91 – 87.92 Mb

PubMed search

Hepatoma-derived growth factor (HDGF) also known as high mobility group protein 1-like 2 (HMG-1L2) is a protein that in humans is encoded by the HDGF gene.^[1]^[2]

References

↑ Wanschura S, Schoenmakers EF, Huysmans C, Bartnitzke S, Van de Ven WJ, Bullerdiek J (May 1997). "Mapping of the gene encoding the human hepatoma-derived growth factor (HDGF) with homology to the high-mobility group (HMG)-1 protein to Xq25". Genomics 32 (2): 298–300. doi:10.1006/geno.1996.0122. PMID 8833162.
↑ "Entrez Gene: HDGF hepatoma-derived growth factor (high-mobility group protein 1-like)".

Everett AD, Bushweller J (2003). "Hepatoma derived growth factor is a nuclear targeted mitogen.". Current drug targets 4 (5): 367–71. doi:10.2174/1389450033490975. PMID 12816346.
Nakamura H, Izumoto Y, Kambe H, et al. (1994). "Molecular cloning of complementary DNA for a novel human hepatoma-derived growth factor. Its homology with high mobility group-1 protein.". J. Biol. Chem. 269 (40): 25143–9. PMID 7929202.
Kishima Y, Yamamoto H, Izumoto Y, et al. (2002). "Hepatoma-derived growth factor stimulates cell growth after translocation to the nucleus by nuclear localization signals.". J. Biol. Chem. 277 (12): 10315–22. doi:10.1074/jbc.M111122200. PMID 11751870.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Mori M, Morishita H, Nakamura H, et al. (2004). "Hepatoma-derived growth factor is involved in lung remodeling by stimulating epithelial growth.". Am. J. Respir. Cell Mol. Biol. 30 (4): 459–69. doi:10.1165/rcmb.2003-0013OC. PMID 12972397.
Yoshida K, Nakamura H, Okuda Y, et al. (2004). "Expression of hepatoma-derived growth factor in hepatocarcinogenesis.". J. Gastroenterol. Hepatol. 18 (11): 1293–301. doi:10.1046/j.1440-1746.2003.03191.x. PMID 14535987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Shu H, Chen S, Bi Q, et al. (2004). "Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.". Mol. Cell Proteomics 3 (3): 279–86. doi:10.1074/mcp.D300003-MCP200. PMID 14729942.
Everett AD, Narron JV, Stoops T, et al. (2004). "Hepatoma-derived growth factor is a pulmonary endothelial cell-expressed angiogenic factor.". Am. J. Physiol. Lung Cell Mol. Physiol. 286 (6): L1194–201. doi:10.1152/ajplung.00427.2003. PMID 14751852.
Sue SC, Chen JY, Huang TH (2004). "Sequence specific 1H, 13C and 15N resonance assignments of the hath-domain of human hepatoma-derived growth factor.". J. Biomol. NMR 29 (1): 95–6. doi:10.1023/B:JNMR.0000019467.57276.05. PMID 15017145.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain.". Mol. Cell Proteomics 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Shen XY, Zacal N, Singh G, Rainbow AJ (2005). "Alterations in mitochondrial and apoptosis-regulating gene expression in photodynamic therapy-resistant variants of HT29 colon carcinoma cells.". Photochem. Photobiol. 81 (2): 306–13. doi:10.1562/2004-07-22-RA-242. PMID 15560738.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.
Iwasaki T, Nakagawa K, Nakamura H, et al. (2005). "Hepatoma-derived growth factor as a prognostic marker in completely resected non-small-cell lung cancer.". Oncol. Rep. 13 (6): 1075–80. doi:10.3892/or.13.6.1075. PMID 15870924.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Beranova-Giorgianni S, Zhao Y, Desiderio DM, Giorgianni F (2006). "Phosphoproteomic analysis of the human pituitary.". Pituitary 9 (2): 109–20. doi:10.1007/s11102-006-8916-x. PMID 16807684.
Clermont F, Gonzalez NS, Communi D, Franken S, Dumont JE, Robaye B (2008). "HDGF is dephosphorylated during the early steps of endothelial cell apoptosis in a caspase-dependent way.". J Cell Biochem 104 (4): 1161–1171. doi:10.1002/jcb.21788. PMID 18465786.

PDB gallery

1ri0: NMR structure of the N-terminal hath domain of human HDGF

2b8a: High Resolution Structure of the HDGF PWWP Domain

This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.

Hepatoma-derived growth factor

References

Further reading