Phenindione

Phenindione
Systematic (IUPAC) name

2-phenyl-1H-indene-1,3(2H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU: D Passes into breast milk
Routes of administration	Oral
Pharmacokinetic data
Protein binding	88%
Biological half-life	5 to 10 hours
Identifiers
CAS Number	83-12-5^Y
ATC code	B01AA02
PubChem	CID 4760
IUPHAR/BPS	6838
DrugBank	DB00498^Y
ChemSpider	4596^Y
UNII	5M7Y6274ZE^Y
KEGG	D08354^Y
ChEBI	CHEBI:8066^Y
ChEMBL	CHEMBL711^Y
Chemical data
Formula	C₁₅H₁₀O₂
Molar mass	222.239 g/mol
SMILES O=C2c1ccccc1C(=O)C2c3ccccc3
InChI InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H^Y Key:NFBAXHOPROOJAW-UHFFFAOYSA-N^Y
(verify)

Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Hypersensitivity has been observed.^[1]

References

↑ Naisbitt DJ, Farrell J, Chamberlain PJ, et al. (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". J. Pharmacol. Exp. Ther. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID 15743920.

External links

DDB 30536

Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

Antiplatelet drugs

Glycoprotein IIb/IIIa inhibitors	Abciximab Eptifibatide Tirofiban Roxifiban Orbofiban

ADP receptor/P2Y₁₂ inhibitors	Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor

Prostaglandin analogue (PGI2)	Beraprost Iloprost Prostacyclin Treprostinil

COX inhibitors	Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal

Thromboxane inhibitors	Thromboxane synthase inhibitors Dipyridamole (+Aspirin) Picotamide Receptor antagonists Terutroban^†

Phosphodiesterase inhibitors	Cilostazol Dipyridamole Triflusal

Other	Cloricromen Ditazole Vorapaxar

Anticoagulants

Vitamin K antagonists
(inhibit II, VII, IX, X)

Factor Xa inhibitors
(with some II inhibition)

Heparin group/ glycosaminoglycans/ (bind antithrombin)	Low molecular weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin^‡ Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide

Direct Xa inhibitors	Xabans Apixaban Betrixaban^† Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban

Direct thrombin (IIa) inhibitors

Other

Thrombolytic drugs/
fibrinolytics

Non-medicinal

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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