Haplogroup R0 (mtDNA)

Haplogroup R0
Possible time of origin 23,600 to 54,900 YBP[1]
Possible place of origin Middle East
Ancestor R
Descendants HV, R0a
Defining mutations 73, 11719[2]

In human mitochondrial genetics, Haplogroup R0 (formerly known as Haplogroup pre-HV[3]) is a mitochondrial DNA (mtDNA) haplogroup.

Origin

Haplogroup R0 derives from the macro-haplogroup R. It is an ancestral haplogroup to R0a and Haplogroup HV, and therefore to Haplogroup H and Haplogroup V.

Distribution

Haplogroup R0 occurs commonly in the Arabian peninsula, with its highest frequency observed among the Socotri (38%).[4] The clade is also found at high frequencies among the Kalash in Central Asia (23%).[5] Additionally, moderate frequencies of R0 occur in North Africa, the Horn of Africa, Anatolia, the Iranian Plateau and Dalmatia. The haplogroup's greater subclade variety in the Arabian peninsula suggests that R0a originated in and spread from there.

Subclades

Tree

This phylogenetic tree of haplogroup R0 subclades is based on the paper by Mannis van Oven and Manfred Kayser Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation[2] and subsequent published research.

See also

Evolutionary tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M   N  
CZ D E G Q   O A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References

  1. ↑ Soares, P; Ermini, L; Thomson, N; Mormina, M; Rito, T; Röhl, A; Salas, A; Oppenheimer, S; et al. (2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". American Journal of Human Genetics 84 (6): 740–59. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
  2. 1 2 van Oven, Mannis; Manfred Kayser (13 Oct 2008). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–E394. doi:10.1002/humu.20921. PMID 18853457. Retrieved 2009-05-20.
  3. ↑ Haplogroup H Sub-clades, Family Tree DNA
  4. ↑ Viktor Cerny et al. 2008, Out of Arabia—The Settlement of Island Soqotra as Revealed by Mitochondrial and Y Chromosome Genetic Diversity.
  5. ↑ Quintana-Murci L, et al. (2004). "Where West Meets East: The Complex mtDNA Landscape of the Southwest and Central Asian Corridor." (PDF). American Journal of Human Genetics 74: 2004. doi:10.1086/383236. PMC 1181978. PMID 15077202.

External links


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