Haplogroup O-MSY2.2

In human genetics, Haplogroup O-MSY2.2 is a Y-chromosome DNA haplogroup. Haplogroup O-MSY2.2 is a descendant branch of the greater Haplogroup O-M175. The great majority of Y-chromosomes within Haplogroup O-MSY2.2 belong to its O-M119 subclade.

Origins

The Haplogroup O-MSY2.2 branch is believed to have evolved during the Late Pleistocene (Upper Paleolithic) in Southeast Asia.

Paleolithic migrations

A 2010 study by Karafet suggests haplogroup O-MSY2.2 was part of a four-phase colonization model in which Paleolithic migrations of hunter-gatherers shaped the primary structure of current Y-Chromosome diversity of Maritime Southeast Asia. Neolithic incursions made only a minor impact on the paternal gene pool, despite the large cultural impact of the Austronesian expansion. Approximately 5000 BCE, Haplogroup O-MSY2.2 coalesced at Sundaland and migrated northwards to as far as Taiwan, where O-M50 constitutes some 90% of the Aboriginal Y-DNA, being the main haplogroup that can be directly linked to the Austronesian expansion in phase 3 (Karafet 2010).

Taiwan homeland

A study by Li in 2008 concluded that in contrast to the Taiwan homeland hypothesis, Island Southeast Asians do not have a Taiwan origin based on their paternal lineages. According to their results, lineages within Maritime Southeast Asia did not originate from Taiwanese aborigines as linguistic studies suggest. Taiwan aborigines and Indonesians were likely to have been derived from the Tai–Kadai-speaking populations based on their paternal lineages, and thereafter evolved independently of each other (Li 2008).

The strongest positive correlation between Haplogroup O-MSY2.2 and ethno-linguistic affiliation is that which is observed between this haplogroup and the Austronesians. The peak frequency of Haplogroup O-MSY2.2 is found among the aborigines of Taiwan, precisely the region from which linguists have hypothesized that the Austronesian language family originated. A slightly weaker correlation is observed between Haplogroup O-MSY2.2 and the Han Chinese populations of southern China, as well as between this haplogroup and the Tai–Kadai-speaking populations of southern China and Southeast Asia. The distribution of Tai–Kadai languages in Thailand and other parts of Southeast Asia outside of China has long been believed, for reasons of traditional linguistic geography, to reflect a recent invasion of Southeast Asia by Tai–Kadai-speaking populations originating from southeastern China, and the somewhat elevated frequency of Haplogroup O-MSY2.2 among the Tai–Kadai populations, coupled with a high frequency of Haplogroup O-M95, which is a genetic characteristic of the Austroasiatic-speaking peoples of Southeast Asia, suggests that the genetic signature of the Tai–Kadai peoples' affinity with populations of southeastern China has been weakened due to extensive assimilation of the earlier Austroasiatic residents of the lands which the Tai–Kadai peoples invaded. Also, it has been noted that Haplogroup O-MSY2.2 lineages among populations of continental Southeast Asia outside of China display a reduced level of diversity when compared with populations of South China and insular Southeast Asia, which may be evidence of a bottleneck associated with the westward migration and settlement of ancestral Tai–Kadai-speaking populations in Indochina.

Distribution

Haplogroup O-MSY2.2 lineages are found primarily in Southeast Asian populations of Malaysia, Vietnam, Indonesia, the Philippines, southern China and Taiwan (ISOGG 2010). High frequencies of this haplogroup have been found in populations spread in an arc through southeastern China, Taiwan, the Philippines, and Indonesia. It has been found with generally lower frequency in samples from Oceania, mainland Southeast Asia, Southwest China, Northwest China, North China, Northeast China, Korea, Japan, North Asia, and Central Asia.

A 2008 study by Li suggested that the admixture analyses of Tai–Kadai-speaking populations showed a significant genetic influence in a large proportion of Indonesians. Most of the population samples contained a high frequency of haplogroup O-M119 (Hui 2008).

The frequencies of Haplogroup O-MSY2.2 among various East Asian and Austronesian populations suggest a complex genetic history of the modern Han populations of southern China. Although Haplogroup O-MSY2.2 occurs only at an average frequency of approximately 4% among Han populations of northern China and peoples of southwestern China and Southeast Asia who speak Tibeto-Burman languages, the frequency of this haplogroup among the Han populations of southern China nearly quadruples to about 15-23%.^[1] The frequency of Haplogroup O-MSY2.2 among the Southern Han has been found to be slightly greater than the arithmetic mean of the frequencies of Haplogroup O-MSY2.2 among the Northern Han and a pooled sample of Austronesian populations. This suggests that modern Southern Han populations may possess a non-trivial number of male ancestors who were originally affiliated with some Austronesian-related culture, or who at least shared some genetic affinity with many of the ancestors of modern Austronesian peoples.^{[2] [3]}

Subclade distribution

O-M119

This lineage is found frequently in Austronesians, southern Han Chinese, and Tai peoples.^[4] This lineage is presumed to be a marker of the prehistoric Austronesian expansion, with possible origins encompassing the regions along the southeastern coast of China and neighboring Taiwan, and is found among modern populations of Maritime Southeast Asia and Oceania (Karafet 2005).

Haplogroup O-M119 Y-chromosomes also have been found to occur at low frequency among various populations of Siberia, such as the Nivkhs (one of 17 sampled Y-chromosomes), Ulchi/Nanai (2/53), Yenisey Evenks (1/31), and especially the Buryats living in the Sayan-Baikal uplands of Irkutsk Oblast (6/13) (Lell 2002).

O-P203

O-P203 was found in 34/48 of Taiwanese Aboriginals, 1/48 of Filipinos, 4/70 of Vietnamese, 1/38 of Malaysians and 15/165 Han Chinese. ^[5]

O-M101

This lineage was observed in one individual from China (Underhill 2000) and another from Kota Kinabalu (Hurles 2005).

O-M50

This lineage occurs among Austronesian peoples of Taiwan, the Philippines, Indonesia, Melanesia, Micronesia, and Madagascar as well as among some populations of continental Southeast Asia.

Phylogenetics

Phylogenetic history

Prior to 2002, there were in academic literature at least seven naming systems for the Y-Chromosome Phylogenetic tree. This led to considerable confusion. In 2002, the major research groups came together and formed the Y-Chromosome Consortium (YCC). They published a joint paper that created a single new tree that all agreed to use. Later, a group of citizen scientists with an interest in population genetics and genetic genealogy formed a working group to create an amateur tree aiming at being above all timely. The table below brings together all of these works at the point of the landmark 2002 YCC Tree. This allows a researcher reviewing older published literature to quickly move between nomenclatures.

Research publications

The following research teams per their publications were represented in the creation of the YCC tree.

Phylogenetic trees

This phylogenetic tree of haplogroup O subclades is based on the YCC 2008 tree (Karafet 2008) and subsequent published research.

• O-MSY2.2 (MSY2.2)
  • O-M119 (M119)
    • O-P203.2 (M307.2/P203.2)
    • O-M50 (M50, M103, M110)

See also

• Austro-Tai languages

Genetics

Y-DNA O subclades

Y-DNA backbone tree

References

Footnotes

Works cited

Journals

• Chen, Chen; Hui, LI; Zhen-Dong, QIN; Wen-Hong, LIU; Wei-Xiong, LIN; Rui-Xing, YIN; Li, JIN; Shang-Ling, PAN (2006). "Y-chromosome Genotyping and Genetic Structure of Zhuang Populations". Acta Genetica Sinica 33 (12): 1060–72. doi:10.1016/S0379-4172(06)60143-1. PMID 17185165. 
• Hammer, Michael F.; Karafet, Tatiana M.; Park, Hwayong; Omoto, Keiichi; Harihara, Shinji; Stoneking, Mark; Horai, Satoshi (2005). "Dual origins of the Japanese: Common ground for hunter-gatherer and farmer Y chromosomes". Journal of Human Genetics 51 (1): 47–58. doi:10.1007/s10038-005-0322-0. PMID 16328082. 
• Hurles, M; Sykes, B; Jobling, M; Forster, P (2005). "The Dual Origin of the Malagasy in Island Southeast Asia and East Africa: Evidence from Maternal and Paternal Lineages". The American Journal of Human Genetics 76 (5): 894–901. doi:10.1086/430051. PMC 1199379. PMID 15793703. 
• Karafet, Tatiana M.; Lansing, J. S.; Redd, Alan J.; Watkins, Joseph C.; Surata, S. P. K.; Arthawiguna, W. A.; Mayer, Laura; Bamshad, Michael; et al. (2005). "Balinese Y-Chromosome Perspective on the Peopling of Indonesia: Genetic Contributions from Pre-Neolithic Hunter-Gatherers, Austronesian Farmers, and Indian Traders". Human Biology 77 (1): 93–114. doi:10.1353/hub.2005.0030. PMID 16114819. 
• Karafet, T. M.; Hallmark, B.; Cox, M. P.; Sudoyo, H.; Downey, S.; Lansing, J. S.; Hammer, M. F. (2010). "Major East-West Division Underlies Y Chromosome Stratification across Indonesia". Molecular Biology and Evolution 27 (8): 1833–44. doi:10.1093/molbev/msq063. PMID 20207712. 
• Kayser, Manfred; Brauer, Silke; Weiss, Gunter; Schiefenhövel, Wulf; Underhill, Peter; Shen, Peidong; Oefner, Peter; Tommaseo-Ponzetta, Mila; Stoneking, Mark (2003). "Reduced Y-Chromosome, but Not Mitochondrial DNA, Diversity in Human Populations from West New Guinea". The American Journal of Human Genetics 72 (2): 281–302. doi:10.1086/346065. PMC 379223. PMID 12532283. 
• Kayser, M.; Choi, Y.; Van Oven, M.; Mona, S.; Brauer, S.; Trent, R. J.; Suarkia, D.; Schiefenhovel, W.; Stoneking, M. (2008). "The Impact of the Austronesian Expansion: Evidence from mtDNA and Y Chromosome Diversity in the Admiralty Islands of Melanesia". Molecular Biology and Evolution 25 (7): 1362–74. doi:10.1093/molbev/msn078. PMID 18390477. 
• Lell, Jeffrey T.; Sukernik, Rem I.; Starikovskaya, Yelena B.; Su, Bing; Jin, Li; Schurr, Theodore G.; Underhill, Peter A.; Wallace, Douglas C. (2002). "The Dual Origin and Siberian Affinities of Native American Y Chromosomes". The American Journal of Human Genetics 70 (1): 192–206. doi:10.1086/338457. PMC 384887. PMID 11731934. 
• Li, Hui; Huang, Ying; Mustavich, Laura F.; Zhang, Fan; Tan, Jing-Ze; Wang, Ling-E; Qian, Ji; Gao, Meng-He; Jin, Li (2007). "Y chromosomes of prehistoric people along the Yangtze River". Human Genetics 122 (3–4): 383–8. doi:10.1007/s00439-007-0407-2. PMID 17657509. 
• Li, Hui; Wen, Bo; Chen, Shu-Juo; Su, Bing; Pramoonjago, Patcharin; Liu, Yangfan; Pan, Shangling; Qin, Zhendong; Liu, Wenhong; Cheng, Xu; Yang, Ningning; Li, Xin; Tran, Dinhbinh; Lu, Daru; Hsu, Mu-Tsu; Deka, Ranjan; Marzuki, Sangkot; Tan, Chia-Chen; Jin, Li (2008). "Paternal genetic affinity between western Austronesians and Daic populations". BMC Evolutionary Biology 8: 146. doi:10.1186/1471-2148-8-146. PMC 2408594. PMID 18482451. 
• MacAulay, Dongna; Li, Hui; Ou, Caiying; Lu, Yan; Sun, Yuantian; Yang, Bo; Qin, Zhendong; Zhou, Zhenjian; et al. (2008). MacAulay, Vincent, ed. "Paternal Genetic Structure of Hainan Aborigines Isolated at the Entrance to East Asia". PLoS ONE 3 (5): e2168. doi:10.1371/journal.pone.0002168. PMC 2374892. PMID 18478090. 
• Su, Bing; Xiao, Junhua; Underhill, Peter; Deka, Ranjan; Zhang, Weiling; Akey, Joshua; Huang, Wei; Shen, Di; et al. (1999). "Y-Chromosome Evidence for a Northward Migration of Modern Humans into Eastern Asia during the Last Ice Age". The American Journal of Human Genetics 65 (6): 1718–24. doi:10.1086/302680. PMC 1288383. PMID 10577926. 
• Tajima, Atsushi; Hayami, Masanori; Tokunaga, Katsushi; Juji, Takeo; Matsuo, Masafumi; Marzuki, Sangkot; Omoto, Keiichi; Horai, Satoshi (2004). "Genetic origins of the Ainu inferred from combined DNA analyses of maternal and paternal lineages". Journal of Human Genetics 49 (4): 187–93. doi:10.1007/s10038-004-0131-x. PMID 14997363. 
• Underhill, Peter A.; Shen, Peidong; Lin, Alice A.; Jin, Li; Passarino, Giuseppe; Yang, Wei H.; Kauffman, Erin; Bonné-Tamir, Batsheva; et al. (2000). "Y chromosome sequence variation and the history of human populations". Nature Genetics 26 (3): 358–61. doi:10.1038/81685. PMID 11062480. 
• Xie, XH; Li, H; Mao, XY; Wen, B; Gao, S; Jin, JZ; Lu, DR; Jin, L (2004). "Genetic structure of Tujia as revealed by Y chromosomes". Acta Genetica Sinica 31 (10): 1023–1029. PMID 15552034. 

Websites

• ISOGG (2010). "Y-DNA Haplogroup O and its Subclades. 2010". International Society of Genetic Genealogy. Retrieved 2010. 

References