Haplogroup M30 (mtDNA)

Haplogroup M30
Possible time of origin 14,600 to 30,200 YBP[1]
Possible place of origin South Asia
Ancestor M4'45
Descendants M30a, M30b, M30c, M30d, M30e
Defining mutations 195A, 15431A, 12007A

In human mitochondrial genetics, Haplogroup M30 is a human mitochondrial DNA (mtDNA) haplogroup.

Origin

Haplogroup M30 (coding region: 195A-514dCA-12007-15431) is a South-Asian[2] or an India-specific maternal lineage[3][4] of the macrohaplogroup M identified by the mutations T195A, G15431A and G12007A.[3]

Haplogroup M30 used to be a part of M4 haplogroup distinguished by G15431A.[5] Haplogroup M30 shares a common coding region mutation (12007) together with the M4, M18, M37 and M38 haplogroups from the root of haplogroup M (superhaplogroup M4'30).[3][6] M4′30 super-clade is the only clade that shares an intermediate lineage between 2 haplogroups, while the rest of all M lineages have originated independently from the root of macrohaplogroup M; thus supporting the idea of rapid dispersal of modern humans along the Asian coast after they left Africa, followed by a long period of isolation.[3]

Haplogroup M30 was identified in 2005 based on complete mitochondrial genome sequences of 24 Indian samples.[7] It was designated as a new lineage with sub-haplogroups M30a, M30b, M30c, M30d based on observed mutations sites. The mutations characterizing this lineage were observed in five samples from eastern part of India, that is Bihar (Kurmi, Yadav and Baniya), West Bengal (Mahishya), Orissa (Saora) and two samples from south India (Christians of Karnataka and Lambadi of Andhra Pradesh). Previously identified Haplogroup M18 was collapsed to reside in M30 as a sub-lineage.[6][7]

In 2006, the definition of M30 was narrowed down by identifying it with the mutations T195A, 15431A and G12007A.[6][8] The study detailed an individual from the Reddy population of Andhra Pradesh categorized into M30a; a sample of Thogataveera from Andhra Pradesh classified into M30b; the presence of M30c in Thogataveera of Andhra Pradesh and Chaturvedi of Uttar Pradesh, and finally, the identification of M30d in Bhargava of Uttar Pradesh and Thogataveera of Andhra Pradesh.[8] In 2009, Subhaplogroup M30e was identified among Kathodi, Kathakur and Mathakur in Western region of India.[9]

In 2006, Sahoo and Kashyap reported haplogroup M30 in Oriya Brahmins, Karanams, Khandayats, Gope (aka Gour or Yadavs);[10] and in tribes of Juang and Saora of Orissa. The Saora exhibited a high frequency of M30 (of about 32% of the sample size) followed by Karanams (24%), Oriya Brahmins (20%) and Juang (20%). Khandayat and Gope showed a lower frequency (about 6%) of M30. M30 was also detected at low frequencies (1.5%–2.5%) in Pardhan, Naikpod Gond and Andh tribal populations of Andhra Pradesh.[8]

The age of M30 lineage was estimated at 33,042 ± 7,840 Years Before Present.[7] However, Thangarajah, et al. (2006) dated it to 15,400 ± 6300 YBP.[8] Rajkumar, et al. put forward the estimated coalescence time of haplogroup M30 to be 15,400 ± 6300 ybp, and that of its sub-haplogroups M30a and M30c to be 5100 ± 3600 ybp.[7] The ages of M30b and M30d were computed to be 4177 ± 2800 years and 12,800 ± 5700 ybp respectively.[8] This period corresponds with the late-Mesolithic in India and the Levant.

Distribution

M30 has a broad geographic, ethnic and linguistic range in India. It has been detected in northern and southern India, in Australoids and Caucasoids, and in Dravidian and Indo-European speakers.[11] This supposedly lends credence to the long speculated possibility of Dravidian speakers migrating through Iran to India. This view is supported by the presence of Indian haplogroups in Iran,[12] and the close relationship between the Dravidian and Elamite languages.[13][14]

M30 haplogroup has been detected in Palestinians and is supposedly due to a recent gene flow from India into that region.[11] M30 is found in Eastern Yemeni populations, Upper Egypt and Kesra (Tunisia), while M30 individuals were found to constitute 7.5% of the total population of Hadramawt (Yemen).[10] Apart from Saudi Arabia, M30 has also been detected in the maternal lineages of China.[6]

To sum up, M30 haplogroup individuals have been found in

Subclades

Tree

This phylogenetic tree of haplogroup subclades is based on the Van Oven 2008 tree[15] and subsequent published research.

See also

Evolutionary tree of human mitochondrial DNA (mtDNA) haplogroups

  Mitochondrial Eve (L)    
L0 L1–6
L1 L2 L3   L4 L5 L6
  M   N  
CZ D E G Q   O A S   R   I W X Y
C Z B F R0   pre-JT P  U
HV JT K
H V J T

References

  1. ↑ Soares, Pedro; Ermini, Luca; Thomson, Noel; Mormina, Maru; Rito, Teresa; Röhl, Arne; Salas, Antonio; Oppenheimer, Stephen; et al. (2009). "Correcting for Purifying Selection: An Improved Human Mitochondrial Molecular Clock". The American Journal of Human Genetics 84 (6): 740–59. doi:10.1016/j.ajhg.2009.05.001. PMC 2694979. PMID 19500773.
  2. ↑ Yonsei University, Korea. The mtDNA Haplogroup Specific Control Region Mutation Motifs
  3. 1 2 3 4 Thangaraj, Kumarasamy; Chaubey, Gyaneshwer; Singh, Vijay; Vanniarajan, Ayyasamy; Thanseem, Ismail; Reddy, Alla G; Singh, Lalji (2006). "In situ origin of deep rooting lineages of mitochondrial Macrohaplogroup 'M' in India". BMC Genomics 7: 151. doi:10.1186/1471-2164-7-151. PMC 1534032. PMID 16776823.
  4. ↑ Sahoo, Sanghamitra; Kashyap, V.K. (2006). "Phylogeography of mitochondrial DNA and Y-Chromosome haplogroups reveal asymmetric gene flow in populations of Eastern India". American Journal of Physical Anthropology 131 (1): 84–97. doi:10.1002/ajpa.20399. PMID 16485297.
  5. ↑ Ian Logan, 2008
  6. 1 2 3 4 Sun, Chang; Kong, Qing-Peng; Palanichamy, Malliya gounder; Agrawal, Suraksha; Bandelt, Hans-Jürgen; Yao, Yong-Gang; Khan, Faisal; Zhu, Chun-Ling; et al. (2005). "The Dazzling Array of Basal Branches in the mtDNA Macrohaplogroup M from India as Inferred from Complete Genomes". Molecular Biology and Evolution 23 (3): 683–90. doi:10.1093/molbev/msj078. PMID 16361303.
  7. 1 2 3 4 Rajkumar, Revathi; Banerjee, Jheelam; Gunturi, Hima; Trivedi, R; Kashyap, VK (2005). "Phylogeny and antiquity of M macrohaplogroup inferred from complete mt DNA sequence of Indian specific lineages". BMC Evolutionary Biology 5: 26. doi:10.1186/1471-2148-5-26. PMC 1079809. PMID 15804362.
  8. 1 2 3 4 5 Maji, Suvendu; Krithika, S; Vasulu, TS (2009). "Phylogeographic distribution of mitochondrial DNA macrohaplogroup M in India" (PDF). Journal of Genetics 88 (1): 127–39. doi:10.1007/s12041-009-0020-3. PMID 19417557.
  9. ↑ Chandrasekar, Adimoolam; Kumar, Satish; Sreenath, Jwalapuram; Sarkar, Bishwa Nath; Urade, Bhaskar Pralhad; Mallick, Sujit; Bandopadhyay, Syam Sundar; Barua, Pinuma; et al. (2009). Quintana-Murci, Lluis, ed. "Updating Phylogeny of Mitochondrial DNA Macrohaplogroup M in India: Dispersal of Modern Human in South Asian Corridor". PLoS ONE 4 (10): e7447. doi:10.1371/journal.pone.0007447. PMC 2757894. PMID 19823670.
  10. 1 2 Černý, Viktor; Mulligan, Connie J.; Rídl, Jakub; Žaloudková, Martina; Edens, Christopher M.; Hájek, Martin; Pereira, Luísa (2008). "Regional differences in the distribution of the sub-Saharan, West Eurasian, and South Asian mtDNA lineages in Yemen". American Journal of Physical Anthropology 136 (2): 128–37. doi:10.1002/ajpa.20784. PMID 18257024.
  11. 1 2 González, Ana M; Larruga, José M; Abu-Amero, Khaled K; Shi, Yufei; Pestano, José; Cabrera, Vicente M (2007). "Mitochondrial lineage M1 traces an early human backflow to Africa". BMC Genomics 8: 223. doi:10.1186/1471-2164-8-223. PMC 1945034. PMID 17620140.
  12. ↑ González, Ana M; Larruga, José M; Abu-Amero, Khaled K; Shi, Yufei; Pestano, José; Cabrera, Vicente M (2007). "Mitochondrial lineage M1 traces an early human backflow to Africa". BMC Genomics 8: 223. doi:10.1186/1471-2164-8-223. PMC 1945034. PMID 17620140.
  13. ↑ McAlpin, David W. (1974). "Toward Proto-Elamo-Dravidian". Language 50 (1): 89–101. doi:10.2307/412012. JSTOR 412012.
  14. ↑ McAlpin, David W. (1981). "Proto-Elamo-Dravidian: The Evidence and Its Implications". Transactions of the American Philosophical Society 71 (3): 1–155. doi:10.2307/1006352. JSTOR 1006352.
  15. ↑ Van Oven, Mannis; Kayser, Manfred (2009). "Updated comprehensive phylogenetic tree of global human mitochondrial DNA variation". Human Mutation 30 (2): E386–94. doi:10.1002/humu.20921. PMID 18853457.

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