Haplogroup K2

This article is about the Y-chromosome haplogroup K2. For the mtDNA haplogroup, see Haplogroup K (mtDNA). For a Y-DNA haplogroup known until 2008 as K2, see Haplogroup T (Y-DNA).
Haplogroup K2
Possible time of origin 47,000-55,000 years BP [1]
Possible place of origin Southeast Asia [2]
Ancestor K
Descendants Haplogroups NO (K2a); K2b (MPS); K2c; K2d; K2e.
Defining mutations rs2033003 (M526)

Haplogroup K2, also known as K-M526 and formerly known as K(xLT) and MNOPS,[3] is a human Y-DNA Haplogroup.

Relative to its age, the internal structure of K2 is extremely complex, and subclades of it are carried by males native to regions including Oceania, South East Asia, East Asia, Central Asia, the Americas, Europe and South Asia.

The only living males reported as carrying the basal paragroup K2* (K-M526) are indigenous Australian males. Up to 27% of them may carry K2* – a further 29% of Aboriginal Australian males may belong to subclades within K2.[4][5]

Ust'-Ishim man, an individual who lived approximately 45,000 BP, in Siberia, also apparently belonged to the paragroup K2*.[1] (There is a remote possibility, however, that the remains of Ust'-Ishim man may belong to a descendant subclade such as Haplogroup NO* or another, as-yet unknown primary branch of K2.)

Structure

A direct descendant of Haplogroup K, K2 is a sibling of basal/paragroup K* and Haplogroup LT (also known as K1).

Haplogroup K2 is the direct ancestral haplogroup to five main descendant subclades:

Distribution

The only living males reported to carry the basal paragroup K2* are indigenous Australians. Major studies published in 2014 and 2015 suggest that up to 27% of Aboriginal Australian males carry K-M526* and others carry a subclade of K2: another 27% probably have K2b1a1 (P60, P304, P308; also known as "S-P308") and perhaps 2.0% have haplogroup M (Y-DNA) (M4; also known as "M-M186".[4][5]

Haplogroup NO (K2a) includes most males among Southeast Asian, East Asian and Finno-Ugric populations.

The descendants of K2b include the major haplogroups M; S, P, Q, and R. These are now numerically in dominant in: Oceania, Central Asia, Siberia, among Native American populations, Europe, and South Asia.

A rapid diversification within and from K2 (M526), most likely in Southeast Asia, is suggested by estimates of the point in time that K2 branched off from K* (M9). Likewise the branching from K2 of K2b (P331) and Haplogroup P (K2b2 P295) from K2b, as well as Haplogroups Q and R from P (K2b2), and their subsequent expansions westward in Europe,[2] and eastward into the Americas.

K2c, K2d, and K2e are extremely rare, minor lineages in specific parts of South and Southeast Asia.[6] K2c (P261) has only been reported among males in Bali, K2d (P402) in Java and K2e (M147) in two modern cases India.[6]

Naming

The name K2 was introduced in 2014, following dissatisfaction with the previous names.

K(xLT), the name introduced by the Y Chromosome Consortium in 2012 to replace MNOPS, was controversial. Under the previous methodology, a term such as "K(xLT)" designated all clades and subclades that belonged to K, but did not belong to Haplogroup LT; the haplogroups subordinate to MNOPS would likely have been renamed "U", "V", "W" and "X", and MNOPS would therefore have become "MNOPSUVWX". This posed a problem, because there was no way to disambiguate between "K(xLT)" in the broad and narrow meanings of the term.

Footnotes

  1. 1 2
  2. 1 2 Karafet et al. 2014
  3. ↑ Chiaroni, Jacques; Underhill, Peter A.; Cavalli-Sforza, Luca L. (2009). "Y chromosome diversity, human expansion, drift, and cultural evolution". PNAS 106: 20174–9. doi:10.1073/pnas.0910803106. PMC 2787129. PMID 19920170.
  4. 1 2 Nagle, N. et al., 2015, "Antiquity and diversity of aboriginal Australian Y-chromosomes", American Journal of Physical Anthropology (epub ahead of print version; abstract). (The authors assumed 56% of the samples taken to be non-indigenous.)
  5. 1 2 Karafet 2014
  6. 1 2 Tatiana M. Karafet, Fernando L. Mendez, Herawati Sudoyo, J. Stephen Lansing and Michael F. Hammer; 2015, "Improved phylogenetic resolution and rapid diversification of Y-chromosome haplogroup K-M526 in Southeast Asia", European Journal of Human Genetics, no. 23 (March), pp. 369–73.
Evolutionary tree of human Y-chromosome DNA haplogroups [χ 1][χ 2]
"Y-chromosomal Adam"
A00 A0-T [χ 3]
A0 A1[χ 4]
A1a A1b
A1b1 BT
B CT
DE CF
D E C F
F1 F2 F3 GHIJK
G HIJK
H IJK
IJ K
I J LT [χ 5]  K2
L T NO [χ 6] K2b [χ 7]   K2c K2d K2e [χ 8]
N O K2b1 [χ 9]    P
M S [χ 10] Q R
  1. ↑ Van Oven M, Van Geystelen A, Kayser M, Decorte R, Larmuseau HD (2014). "Seeing the wood for the trees: a minimal reference phylogeny for the human Y chromosome". Human Mutation 35 (2): 187–91. doi:10.1002/humu.22468. PMID 24166809.
  2. ↑ International Society of Genetic Genealogy (ISOGG; 2015), Y-DNA Haplogroup Tree 2015. (Access date: 1 February 2015.)
  3. ↑ Haplogroup A0-T is also known as A0'1'2'3'4.
  4. ↑ Haplogroup A1 is also known as A1'2'3'4.
  5. ↑ Haplogroup LT (L298/P326) is also known as Haplogroup K1.
  6. ↑ Haplogroup NO (M214) is also known as Haplogroup K2a (although the present Haplogroup K2e was also previously known as "K2a").
  7. ↑ Haplogroup K2b (M1221/P331/PF5911) is also known as Haplogroup MPS.
  8. ↑ Haplogroup K2e (K-M147) was previously known as "Haplogroup X" and "K2a" (but is a sibling subclade of the present K2a, also known as Haplogroup NO).
  9. ↑ Haplogroup K2b1 (P397/P399) is similiar to the former Haplogroup MS, but has a broader and more complex internal structure.
  10. ↑ Haplogroup S (S-M230) was previously known as Haplogroup K5.
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