Halimadienyl-diphosphate synthase

Halimadienyl-diphosphate synthase
Identifiers
EC number 5.5.1.16
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Halimadienyl-diphosphate synthase (EC 5.5.1.16, Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with system name halima-5,13-dien-15-yl-diphosphate lyase (decyclizing).[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate \rightleftharpoons tuberculosinyl diphosphate

This enzyme requires Mg2+ for activity.

References

  1. Nakano, C., Okamura, T., Sato, T., Dairi, T. and Hoshino, T. (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton". Chem. Commun. (Camb.) (8): 1016–1018. doi:10.1039/b415346d. PMID 15719101.

External links

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