HLA-B45


HLA-B (alpha)-β2MG with bound peptide
major histocompatibility complex (human), class I, B45
Alleles	B*4501, 4502 . .
Structure (See HLA-B)
Shared data
Locus	chr.6 6p21.31

HLA-B45 (B45) is an HLA-B serotype. The serotype identifies the B*45 gene-allele protein products of HLA-B.^[1]

Further information: HLA-serotype tutorial

B45 is a split antigen of the broad antigen B12, and is a sister type of B44.

Serotype

Serotypes B45, B12, and B44 recognition of the
HLA B*44 gene products^[2]
B*45	B45	B12	B45	Sample
allele	%	%	%	size (N)
*4501	93	1	1	2307
*4502	75			4
Alleles link-out to IMGT/HLA Databease at EBI

Alleles

It was reported that a novel haplotype was found in Italian bone marrow doners. A2-CW*1601-B45- DRB1*1101-DRB3*0301-DQA1*0102-DQB1*0502. This haplotype indicates possible very recent ancestry from Africa, with the Cw*1601 and B45 components and also with the DR11-DQ5.2 component both extremely rare in Europe.^[3]

References

↑ Marsh SG, Albert ED, Bodmer WF, et al. (2005). "Nomenclature for factors of the HLA system, 2004". Tissue Antigens 65 (4): 301–69. doi:10.1111/j.1399-0039.2005.00379.x. PMID 15787720.
↑ derived from IMGT/HLA
↑ Daielli C, Salvaneschi L, Ghidini G, Ambroselli F, Gatti C, Martinetti M (April 1996). "A novel Italian haplotype predominates in HLA-B45-positive bone marrow donors: HLA-A2, CW*1601, B45, DRB1*1101, DRB3*0301, DQA1*0102, DQB1*0502". Tissue Antigens 47 (4): 341–3. doi:10.1111/j.1399-0039.1996.tb02564.x. PMID 8773326.

HLA-B serotypes and allele groups

HLA-B B5 B51 B52 B7 B8 B12 B44 B45 B13 B14 B64 B65 B15 B62 B63 B70 B71 B72 B75 B76 B77 B16 B38 B39 B17 B57 B58 B18 B21 B49 B50 B22 B54 B55 B56 B27 B35 B37 B40 B60 B61 B41 B42 B46 B47 B48 B53 B59 B67 B73 B78 B81 B82 B83

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