Asoxime chloride

Asoxime chloride
Systematic (IUPAC) name

4-carbamoyl-1-[({2-[(E)-(hydroxyimino)methyl]pyridinium-1-yl}methoxy)methyl]pyridinium dichloride
Clinical data
Legal status	Experimental
Routes of administration	Intramuscular injection
Identifiers
CAS Number	34433-31-3^N
ATC code	None
PubChem	CID 5484128
ChemSpider	13004322^Y
ChEMBL	CHEMBL33051^Y
Chemical data
Formula	C₁₄H₁₆Cl₂N₄O₃
Molar mass	359.21 g/mol
SMILES C1=CC=[N+](C(=C1)/C=N/O)COC[N+]2=CC=C(C=C2)C(=O)N.[Cl-].[Cl-]
InChI InChI=1S/C14H14N4O3.2ClH/c15-14(19)12-4-7-17(8-5-12)10-21-11-18-6-2-1-3-13(18)9-16-20;;/h1-9H,10-11H2,(H-,15,19);2*1H^Y Key:QELSIJXWEROXOE-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

Asoxime chloride, or more commonly HI-6, is a Hagedorn oxime used in the treatment of organophosphate poisoning.^[1]

References

↑ Cochran, R.; Kalisiak, J.; Küçükkilinç, T.; Radic, Z.; Garcia, E.; Zhang, L.; Ho, K. -Y.; Amitai, G.; Kovarik, Z.; Fokin, V. V.; Sharpless, K. B.; Taylor, P. (2011). "Oxime-assisted Acetylcholinesterase Catalytic Scavengers of Organophosphates That Resist Aging". Journal of Biological Chemistry 286 (34): 29718–29724. doi:10.1074/jbc.M111.264739. PMC 3191013. PMID 21730071.

Antidotes (V03AB)

Nervous
system

Nerve agent / Organophosphate poisoning	Atropine^# Biperiden Diazepam^# Oximes Obidoxime Pralidoxime see also: Cholinesterase

Barbiturate overdose	Bemegride Ethamivan

Benzodiazepine overdose	Cyprodenate Flumazenil

GHB overdose	Physostigmine SCH-50911

Opioid overdose	Diprenorphine Doxapram Nalmefene Nalorphine Naloxone^# Naltrexone

Reversal of neuromuscular blockade	Sugammadex

Circulatory
system

Beta blocker	Glucagon

Digoxin toxicity	Digoxin Immune Fab

Heparin	Protamine^#

Other

Arsenic poisoning	Dimercaprol^# Succimer

Cyanide poisoning	4-Dimethylaminophenol Hydroxocobalamin nitrite Amyl nitrite Sodium nitrite^# Sodium thiosulfate^#

Hydrofluoric acid	Calcium gluconate^#

Methanol / Ethylene glycol poisoning	Primary alcohols: Ethanol Fomepizole

Paracetamol toxicity (Acetaminophen)	Acetylcysteine^# Glutathione Methionine^#

Toxic metals (cadmium lead mercury thallium)	Dimercaprol^# Edetates Prussian blue^#

Other	iodine-131 Potassium iodide Methylthioninium chloride^# oxidizing agent Potassium permanganate Prednisolone/promethazine

Emetic

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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