HERC5

HECT and RLD domain containing E3 ubiquitin protein ligase 5

Identifiers

HERC5 ; CEB1; CEBP1

External IDs

OMIM: 608242 HomoloGene: 81848 GeneCards: HERC5 Gene

Gene ontology
Molecular function	• ubiquitin-protein transferase activity • protein binding • ligase activity • ISG15 transferase activity • poly(A) RNA binding
Cellular component	• cytoplasm • cytosol • perinuclear region of cytoplasm
Biological process	• regulation of cyclin-dependent protein serine/threonine kinase activity • cytokine-mediated signaling pathway • ISG15-protein conjugation • negative regulation of type I interferon production • protein ubiquitination involved in ubiquitin-dependent protein catabolic process • innate immune response • regulation of defense response to virus • defense response to virus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

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RefSeq (mRNA)

NM_016323

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RefSeq (protein)

NP_057407

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Location (UCSC)

Chr 4:
88.46 – 88.51 Mb

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PubMed search

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Probable E3 ubiquitin-protein ligase HERC5 is an enzyme that in humans is encoded by the HERC5 gene.^[1]^[2]

This gene is a member of the HERC family of ubiquitin ligases and encodes a protein with a HECT domain and five RCC1 repeats. Pro-inflammatory cytokines upregulate expression of this gene in endothelial cells. The protein localizes to the cytoplasm and perinuclear region and functions as an interferon-induced E3 protein ligase that mediates ISGylation of protein targets. The gene lies in a cluster of HERC family genes on chromosome 4.^[2] HERC5 has been shown to exhibit antiviral activity towards HIV-1, influenza A virus and human papillomavirus.^[3]^[4]^[5]

Interactions

HERC5 has been shown to interact with NME2^[6] and Cyclin E1.^[1]

References

1 2 Mitsui K, Nakanishi M, Ohtsuka S, Norwood TH, Okabayashi K, Miyamoto C, Tanaka K, Yoshimura A, Ohtsubo M (Jan 2000). "A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins". Biochem Biophys Res Commun 266 (1): 115–22. doi:10.1006/bbrc.1999.1777. PMID 10581175.
1 2 "Entrez Gene: HERC5 hect domain and RLD 5".
↑ Woods MW, Kelly JN, Hattlmann CJ, Tong JG, Xu LS, Coleman MD, Quest GR, Smiley JR, Barr SD (Nov 2011). "Human HERC5 restricts an early stage of HIV-1 assembly by a mechanism correlating with the ISGylation of Gag". Retrovirology 8: 95. doi:10.1186/1742-4690-8-95. PMID 22093708.
↑ Tang Y, Zhong G, Zhu L, Liu X, Shan Y, Feng H, Bu Z, Chen H, Wang C (May 2010). "Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein". J Immunol 184 (10): 5777–90. doi:10.4049/jimmunol.0903588. PMID 20385878.
↑ Durfee LA, Lyon N, Seo K, Huibregtse JM (June 2010). "The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15". Mol Cell 38 (5): 722–32. doi:10.1016/j.molcel.2010.05.002. PMID 20542004.
↑ Hochrainer, K; Kroismayr R; Baranyi U; Binder B R; Lipp J (Jul 2008). "Highly homologous HERC proteins localize to endosomes and exhibit specific interactions with hPLIC and Nm23B". Cell. Mol. Life Sci. (Switzerland) 65 (13): 2105–17. doi:10.1007/s00018-008-8148-5. ISSN 1420-682X. PMID 18535780.

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