HERC1

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols HERC1 ; p532; p619
External IDs OMIM: 605109 MGI: 2384589 HomoloGene: 31207 GeneCards: HERC1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8925 235439
Ensembl ENSG00000103657 ENSMUSG00000038664
UniProt Q15751 E9PZP8
RefSeq (mRNA) NM_003922 NM_145617
RefSeq (protein) NP_003913 NP_663592
Location (UCSC) Chr 15:
63.61 – 63.83 Mb
Chr 9:
66.35 – 66.51 Mb
PubMed search

Probable E3 ubiquitin-protein ligase HERC1 is an enzyme that in humans is encoded by the HERC1 gene.[1][2][3]

The protein encoded by this gene stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein is thought to be involved in membrane transport processes[3]

References

  1. Rosa JL, Casaroli-Marano RP, Buckler AJ, Vilaro S, Barbacid M (Dec 1996). "p619, a giant protein related to the chromosome condensation regulator RCC1, stimulates guanine nucleotide exchange on ARF1 and Rab proteins". EMBO J 15 (16): 4262–73. PMC 452152. PMID 8861955.
  2. Rosa JL, Barbacid M (Aug 1997). "A giant protein that stimulates guanine nucleotide exchange on ARF1 and Rab proteins forms a cytosolic ternary complex with clathrin and Hsp70". Oncogene 15 (1): 1–6. doi:10.1038/sj.onc.1201170. PMID 9233772.
  3. 1 2 "Entrez Gene: HERC1 hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1".

Further reading


This article is issued from Wikipedia - version of the Tuesday, September 01, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.