HEAT repeat domain
| HEAT repeat | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Structure of the protein phosphatase 2A PR65/A subunit revealing the conformation of its 15 tandemly repeated HEAT motifs.[1] | |||||||||
| Identifiers | |||||||||
| Symbol | HEAT | ||||||||
| Pfam | PF02985 | ||||||||
| InterPro | IPR000357 | ||||||||
| PROSITE | PDOC50077 | ||||||||
| SCOP | 1b3u | ||||||||
| SUPERFAMILY | 1b3u | ||||||||
| |||||||||
The HEAT repeat domain is a solenoid protein domain found in a number of cytoplasmic proteins including the four that the give rise to the acronym HEAT (Huntingtin, elongation factor 3 (EF3), protein phosphatase 2A (PP2A), and the yeast kinase TOR1).[2] HEAT repeats form rod-like helical structures which are involved in intracellular transport; they are structurally related to armadillo repeats. The nuclear transport protein importin beta contains 19 HEAT repeats.
References
- ↑ Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs". Cell 96 (1): 99–110. doi:10.1016/S0092-8674(00)80963-0. PMID 9989501.
- ↑ Andrade MA, Bork P (October 1995). "HEAT repeats in the Huntington's disease protein". Nat. Genet. 11 (2): 115–6. doi:10.1038/ng1095-115. PMID 7550332.
External links
- Eukaryotic Linear Motif resource motif class LIG_PIKK_1
- Eukaryotic Linear Motif resource motif class DOC_PIKK_1
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