HCLS1

Hematopoietic cell-specific Lyn substrate 1
Identifiers
Symbols HCLS1 ; CTTNL; HS1; lckBP1; p75
External IDs OMIM: 601306 MGI: 104568 HomoloGene: 38034 GeneCards: HCLS1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 3059 15163
Ensembl ENSG00000180353 ENSMUSG00000022831
UniProt P14317 P49710
RefSeq (mRNA) NM_001292041 NM_008225
RefSeq (protein) NP_001278970 NP_032251
Location (UCSC) Chr 3:
121.63 – 121.66 Mb
Chr 16:
36.93 – 36.96 Mb
PubMed search

Hematopoietic lineage cell-specific protein is a protein that in humans is encoded by the HCLS1 gene.[1][2][3]

Interactions

HCLS1 has been shown to interact with Caspase 3.[4][5]

References

  1. Egashira M, Kitamura D, Watanabe T, Niikawa N (Jan 1997). "The human HCLS1 gene maps to chromosome 3q13 by fluorescence in situ hybridization". Cytogenet Cell Genet 72 (2-3): 175–6. doi:10.1159/000134179. PMID 8978766.
  2. van Rossum AG, Schuuring-Scholtes E, van Buuren-van Seggelen V, Kluin PM, Schuuring E (Mar 2005). "Comparative genome analysis of cortactin and HS1: the significance of the F-actin binding repeat domain". BMC Genomics 6: 15. doi:10.1186/1471-2164-6-15. PMC 554100. PMID 15710041.
  3. "Entrez Gene: HCLS1 hematopoietic cell-specific Lyn substrate 1".
  4. Ruzzene, Maria; Penzo Daniele; Pinna Lorenzo A (May 2002). "Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells". Biochem. J. (England) 364 (Pt 1): 41–7. ISSN 0264-6021. PMC 1222543. PMID 11988074.
  5. Chen, Y R; Kori R; John B; Tan T H (Nov 2001). "Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis". Biochem. Biophys. Res. Commun. (United States) 288 (4): 981–9. doi:10.1006/bbrc.2001.5862. ISSN 0006-291X. PMID 11689006.

Further reading

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