H2AFY2

H2A histone family, member Y2

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2XD7

Identifiers

Symbols

H2AFY2 ; macroH2A2

External IDs

OMIM: 616141 MGI: 3037658 HomoloGene: 10246 GeneCards: H2AFY2 Gene

Gene ontology
Molecular function	• RNA polymerase II regulatory region sequence-specific DNA binding • chromatin DNA binding • transcription regulatory region DNA binding • protein heterodimerization activity
Cellular component	• nucleosome • nuclear chromatin • Barr body • nucleus • nucleoplasm • ESC/E(Z) complex • extracellular exosome
Biological process	• negative regulation of transcription from RNA polymerase II promoter • regulation of cell growth • nucleosome assembly • brain development • dosage compensation • chromatin modification • positive regulation of keratinocyte differentiation • negative regulation of gene expression, epigenetic • establishment of protein localization to chromatin • negative regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
70.05 – 70.11 Mb

Chr 10:
61.74 – 61.78 Mb

PubMed search

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene.^[1]^[2]^[3]

References

↑ Chadwick BP, Willard HF (May 2001). "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant". Hum Mol Genet 10 (10): 1101–13. doi:10.1093/hmg/10.10.1101. PMID 11331621.
↑ Costanzi C, Pehrson JR (Jun 2001). "MACROH2A2, a new member of the MARCOH2A core histone family". J Biol Chem 276 (24): 21776–84. doi:10.1074/jbc.M010919200. PMID 11262398.
↑ "Entrez Gene: H2AFY2 H2A histone family, member Y2".

El Kharroubi A, Piras G, Zensen R, Martin MA (1998). "Transcriptional activation of the integrated chromatin-associated human immunodeficiency virus type 1 promoter.". Mol. Cell. Biol. 18 (5): 2535–44. PMC 110633. PMID 9566873.
Deng L, de la Fuente C, Fu P, et al. (2001). "Acetylation of HIV-1 Tat by CBP/P300 increases transcription of integrated HIV-1 genome and enhances binding to core histones.". Virology 277 (2): 278–95. doi:10.1006/viro.2000.0593. PMID 11080476.
Deng L, Wang D, de la Fuente C, et al. (2001). "Enhancement of the p300 HAT activity by HIV-1 Tat on chromatin DNA.". Virology 289 (2): 312–26. doi:10.1006/viro.2001.1129. PMID 11689053.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lusic M, Marcello A, Cereseto A, Giacca M (2004). "Regulation of HIV-1 gene expression by histone acetylation and factor recruitment at the LTR promoter.". EMBO J. 22 (24): 6550–61. doi:10.1093/emboj/cdg631. PMC 291826. PMID 14657027.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Zhang R, Poustovoitov MV, Ye X, et al. (2005). "Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA.". Dev. Cell 8 (1): 19–30. doi:10.1016/j.devcel.2004.10.019. PMID 15621527.

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H2AFY2

References

Further reading