Growth hormone-binding protein

growth hormone receptor
Identifiers
Symbol	GHR
Entrez	2690
HUGO	4263
OMIM	600946
RefSeq	NM_000163
UniProt	P10912
Other data
Locus	Chr. 5 p13-p12

Growth hormone-binding protein (GHBP) is a carrier protein for growth hormone.

It is coded by the same gene as growth hormone receptor. When this gene is translated into a protein the extracellular domain of the receptor is cleaved in order to produce GHBP.^[1]

Low levels of Growth Hormone binding protein may indicate a growth hormone receptor problem, and thus a growth hormone insensitivity, rather than a growth hormone deficiency. Normal serum levels of growth hormone Binding Protein 3 may rule out growth hormone insensitivities, like those seen in Laron syndrome.

References

↑ Fisker, Sanne. "Physiology and pathophysiology of growth hormone-binding protein: Methodological and clinical aspects". Growth Hormone & IGF Research 16 (1): 1–28. doi:10.1016/j.ghir.2005.11.001.

External links

somatotropin-binding protein at the US National Library of Medicine Medical Subject Headings (MeSH)
Baumann, Gerhard; Shaw, Melissa A.; Winter, Robert J. (1987). "Absence of the Plasma Growth Hormone-Binding Protein in Laron-Type Dwarfism". Journal of Clinical Endocrinology & Metabolism 65 (4): 814–6. doi:10.1210/jcem-65-4-814. PMID 3654924.

Proteins: carrier proteins

Fatty acid	FABP1 FABP2 FABP3 FABP4 FABP5 FABP6 FABP7

Hormone	peptide hormone: Follistatin Growth hormone binding protein Insulin-like growth factor binding protein IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 IGFBP7 Neurophysins Neurophysin I II steroid hormone: Sex hormone binding globulin/Androgen binding protein Transcortin Thyroxine-binding globulin Transthyretin

Metal/element	calcium Calcium-binding protein Calmodulin-binding proteins copper Ceruloplasmin iron Iron-binding proteins Transferrin receptor

Vitamin	Retinol binding protein 1 2 3 4 Transcobalamin

Pigment	Plant Light-Harvesting Complex Orange Carotenoid Protein Phycobiliprotein Photosynthetic Reaction Centers Phytochrome Rhodopsin

Other	Acyl carrier protein Adaptor protein Cholesterylester transfer protein F-box protein GTP-binding protein Latent TGF-beta binding protein Major urinary proteins Membrane transport protein Odorant binding protein

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