Growth-hormone-releasing hormone receptor

Growth hormone releasing hormone receptor
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2XDG​
Identifiers
Symbols	GHRHR ; GHRFR; GRFR; IGHD1B
External IDs	OMIM: 139191 MGI: 95710 HomoloGene: 640 IUPHAR: 247 ChEMBL: 2032 GeneCards: GHRHR Gene
Gene ontology Molecular function • G-protein coupled receptor activity • protein binding • growth hormone-releasing hormone receptor activity • peptide hormone binding • growth factor binding Cellular component • nuclear inner membrane • nuclear outer membrane • cytoplasm • plasma membrane • cell surface • integral component of membrane • nuclear matrix • secretory granule Biological process • cell surface receptor signaling pathway • adenylate cyclase-activating G-protein coupled receptor signaling pathway • activation of adenylate cyclase activity • lactation • positive regulation of cell proliferation • determination of adult lifespan • cAMP-mediated signaling • water homeostasis • growth hormone secretion • positive regulation of cAMP biosynthetic process • response to insulin • cellular response to insulin stimulus • regulation of intracellular steroid hormone receptor signaling pathway • positive regulation of multicellular organism growth • hormone metabolic process • positive regulation of insulin-like growth factor receptor signaling pathway • response to estrogen • cell maturation • multicellular organismal reproductive process • regulation of protein metabolic process • response to glucocorticoid • positive regulation of growth hormone secretion • somatotropin secreting cell development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2692	14602
Ensembl	ENSG00000106128	ENSMUSG00000004654
UniProt	Q02643	P32082
RefSeq (mRNA)	NM_000823	NM_001003685
RefSeq (protein)	NP_000814	NP_001003685
Location (UCSC)	Chr 7: 30.94 – 30.99 Mb	Chr 6: 55.38 – 55.39 Mb
PubMed search

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via Adenylate cyclase.^[1]

This gene, expressed in the pituitary, encodes a receptor for growth-hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth-hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. Many alternate transcriptional splice variants encoding different isoforms have been described, but only two have been characterized to date.^[2]

Ligands

Agonists

• CJC-1295
• Dumorelin
• GHRH (somatorelin)
• Rismorelin
• Sermorelin
• Tesamorelin

Antagonists

• MZ-5-156^[3][4]

References

1. ↑ Gaylinn BD (2002). "Growth hormone releasing hormone receptor". Recept. Channels 8 (3–4): 155–62. doi:10.1080/10606820213679. PMID 12529933. 
2. ↑ "Entrez Gene: GHRHR growth hormone releasing hormone receptor". 
3. ↑ Kovács M, Schally AV, Zarándi M, Groot K (1997). "Inhibition of GH release of rats by new potent antagonists of growth hormone-releasing hormone (GH-RH)". Peptides 18 (3): 431–8. doi:10.1016/S0196-9781(96)00334-8. PMID 9145432. 
4. ↑ Banks WA, Morley JE, Farr SA, Price TO, Ercal N, Vidaurre I, Schally AV (December 2010). "Effects of a growth hormone-releasing hormone antagonist on telomerase activity, oxidative stress, longevity, and aging in mice". Proceedings of the National Academy of Sciences of the United States of America 107 (51): 22272–7. doi:10.1073/pnas.1016369107. PMC 3009756. PMID 21135231. 

Further reading

External links

• IUPHAR GPCR Database – GHRH receptor
• somatotropin releasing hormone receptor at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.