Graft versus tumor effect

Graft versus tumor effect (GvT) appears after allogeneic hematopoietic stem cell transplantation (HSCT). The graft contains donor T lymphocytes that are beneficial for recipient. Donor T-cells eliminate malignant residual host T-cells (graft versus leukemia) or eliminates diverse kinds of tumors.[1] GvT might develop after recognizing tumor-specific or recipient-specific alloantigens.[99] It could lead to remission or immune control of hematologic malignancies.[2] This effect applies in myeloma and lymphoid leukemias, lymphoma, multiple myeloma and possibly breast cancer.[3] It is closely linked with graft versus host disease phenoma (GvHD). CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect.[4] The biology of GvT response still isn’t fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved.[5][6] This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT.[6]

See also

References

  1. ↑ Thompson LF, Tsukamoto H, Chernogorova P, Zeiser R (2013). "A delicate balance: CD73-generated adenosine limits the severity of graft vs. host disease but also constrains the allogeneic graft vs. tumor effect". Oncoimmunology 2 (1): e22107. doi:10.4161/onci.22107. PMC 3583907. PMID 23482243.
  2. ↑ Kolb HJ (2008). "Graft-versus-leukemia effects of transplantation and donor lymphocytes". Blood 112 (12): 4371–83. doi:10.1182/blood-2008-03-077974. PMID 19029455.
  3. ↑ Childs RW, Clave E, Tisdale J, Plante M, Hensel N, Barrett J (1999). "Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect". J Clin Oncol 17 (7): 2044–9. PMID 10561256.
  4. ↑ Vagianos C, Polydorou A, Karatzas T, Vagenas C, Stavropoulos M, Androulakis J (1992). "Successful treatment of postoperative external biliary fistula by selective nasobiliary drainage". HPB Surg 6 (2): 115–20; discussion 120–4. doi:10.1155/1992/58436. PMC 2443016. PMID 1292584.
  5. ↑ Baron F, Maris MB, Sandmaier BM, Storer BE, Sorror M, Diaconescu R et al. (2005). "Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning". J Clin Oncol 23 (9): 1993–2003. doi:10.1200/JCO.2005.08.136. PMID 15774790.
  6. 1 2 Rezvani AR, Storb RF (2008). "Separation of graft-vs.-tumor effects from graft-vs.-host disease in allogeneic hematopoietic cell transplantation". J Autoimmun 30 (3): 172–9. doi:10.1016/j.jaut.2007.12.002. PMC 2329571. PMID 18242060.


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