Globoside

A globoside is a type of glycosphingolipid with more than one sugar as the side chain (or R group) of ceramide. The sugars are usually a combination of N-acetylgalactosamine, D-glucose or D-galactose. A glycosphingolipid that has only one sugar as the side chain is called a cerebroside.

The side chain can be cleaved by galactosidases and glucosidases. The deficiency of α-galactosidase A causes Fabry's disease, an inherited metabolic disease characterized by the accumulation of the globoside globotriaosylceramide.

External links

Globosides at the US National Library of Medicine Medical Subject Headings (MeSH)

Glycoconjugates, lipids and glycolipids: sphingolipids and glycosphingolipids, and metabolic intermediates

Ceramide

Ganglioside
pathway

From ganglioside	GM1 GM2 GD2

From globoside	Globotriaosylceramide

From sphingomyelin	Glucocerebroside

From sulfatide	Galactocerebroside

To sphingosine	Ceramide

Other

Sphingosine-1-phosphate

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