GTF3C4

General transcription factor IIIC, polypeptide 4, 90kDa

Identifiers

GTF3C4 ; KAT12; TFIII90; TFIIIC290; TFIIIC90; TFIIICDELTA

External IDs

OMIM: 604892 MGI: 2138937 HomoloGene: 8147 GeneCards: GTF3C4 Gene

Gene ontology
Molecular function	• DNA binding • histone acetyltransferase activity • protein binding • enzyme activator activity
Cellular component	• transcription factor TFIIIC complex • nucleoplasm
Biological process	• transcription, DNA-templated • transcription from RNA polymerase III promoter • transcription initiation from RNA polymerase III promoter • gene expression • histone acetylation • 5S class rRNA transcription from RNA polymerase III type 1 promoter • tRNA transcription from RNA polymerase III promoter • positive regulation of catalytic activity
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000125484

ENSMUSG00000035666

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
132.67 – 132.69 Mb

Chr 2:
28.82 – 28.84 Mb

PubMed search

General transcription factor 3C polypeptide 4 is a protein that in humans is encoded by the GTF3C4 gene.^[1]^[2]

Interactions

GTF3C4 has been shown to interact with GTF3C2,^[1] GTF3C1,^[1] POLR3C^[1]^[3] and GTF3C5.^[1]

References

1 2 3 4 5 Hsieh YJ, Kundu TK, Wang Z, Kovelman R, Roeder RG (Nov 1999). "The TFIIIC90 subunit of TFIIIC interacts with multiple components of the RNA polymerase III machinery and contains a histone-specific acetyltransferase activity". Mol. Cell. Biol. 19 (11): 7697–704. PMC 84812. PMID 10523658.
↑ "Entrez Gene: GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa".
↑ Hsieh YJ, Wang Z, Kovelman R, Roeder RG (Jul 1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.

Further reading

Dumay-Odelot H, Marck C, Durrieu-Gaillard S, Lefebvre O, Jourdain S, Prochazkova M, Pflieger A, Teichmann M (2007). "Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC". J. Biol. Chem. 282 (23): 17179–89. doi:10.1074/jbc.M611542200. PMID 17409385.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Hsieh YJ, Wang Z, Kovelman R, Roeder RG (1999). "Cloning and characterization of two evolutionarily conserved subunits (TFIIIC102 and TFIIIC63) of human TFIIIC and their involvement in functional interactions with TFIIIB and RNA polymerase III". Mol. Cell. Biol. 19 (7): 4944–52. PMC 84305. PMID 10373544.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.

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