GPX8

Glutathione peroxidase 8 (putative)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3CYN, 3KIJ

Identifiers

Symbols

GPX8 ; EPLA847; GPx-8; GSHPx-8; UNQ847

External IDs

MGI: 1916840 HomoloGene: 88454 GeneCards: GPX8 Gene

EC number

1.11.1.9

Gene ontology
Molecular function	• peroxidase activity • glutathione peroxidase activity
Cellular component	• endoplasmic reticulum lumen • integral component of membrane
Biological process	• response to reactive oxygen species • oxidation-reduction process
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
55.16 – 55.17 Mb

Chr 13:
113.04 – 113.05 Mb

PubMed search

Glutathione peroxidase 8 (GPx-8) is an enzyme that in humans is encoded by the GPX8 gene.^[1]^[2] GPx-8 is a member of the glutathione peroxidase family.

References

↑ "Entrez Gene: glutathione peroxidase 8 (putative)".
↑ Toppo S, Vanin S, Bosello V, Tosatto SC (September 2008). "Evolutionary and structural insights into the multifaceted glutathione peroxidase (Gpx) superfamily". Antioxid. Redox Signal. 10 (9): 1501–14. doi:10.1089/ars.2008.2057. PMID 18498225.

Oxidoreductases: peroxidases (EC 1.11)

1.11.1.1-14	Catalase Cytochrome c peroxidase Eosinophil peroxidase Glutathione peroxidase GPX 1 2 3 4 5 6 7 8 Horseradish peroxidase Lactoperoxidase Myeloperoxidase Thyroid peroxidase Deiodinase Iodothyronine deiodinase Iodotyrosine deiodinase

1.11.1.15 (peroxiredoxin)	1 2 3 4 5 6

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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