GIMAP5

GTPase, IMAP family member 5

Identifiers

GIMAP5 ; HIMAP3; IAN-5; IAN4; IAN4L1; IAN5; IMAP3; IROD

External IDs

OMIM: 608086 MGI: 2442232 HomoloGene: 130695 GeneCards: GIMAP5 Gene

Gene ontology
Molecular function	• protein binding • GTP binding
Cellular component	• mitochondrial outer membrane • lysosome • integral component of membrane
Biological process	• temperature homeostasis • positive regulation of natural killer cell cytokine production • positive regulation of humoral immune response mediated by circulating immunoglobulin • positive regulation of calcium ion transport into cytosol • T cell differentiation • negative regulation of interferon-gamma production • positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation • myeloid dendritic cell differentiation • T cell homeostasis • negative regulation of apoptotic process • negative regulation of nitric oxide biosynthetic process • positive regulation of gamma-delta T cell differentiation • positive regulation of membrane potential • positive regulation of natural killer cell mediated cytotoxicity • regulation of mitochondrial membrane permeability • negative regulation of T cell activation • negative regulation of lipid catabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
150.72 – 150.75 Mb

Chr 6:
48.77 – 48.77 Mb

PubMed search

GTPase IMAP family member 5 is an enzyme that in humans is encoded by the GIMAP5 gene.^[1]

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1.^[1]

References

1 2 "Entrez Gene: GIMAP5 GTPase, IMAP family member 5".

Dahéron L, Zenz T, Siracusa LD; et al. (2001). "Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an outer membrane mitochondrial protein with GTP-binding activity.". Nucleic Acids Res. 29 (6): 1308–16. doi:10.1093/nar/29.6.1308. PMC 29751. PMID 11238997.
Stamm O, Krücken J, Schmitt-Wrede HP; et al. (2002). "Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.". Gene 282 (1–2): 159–67. doi:10.1016/S0378-1119(01)00837-X. PMID 11814688.
Cambot M, Aresta S, Kahn-Perlès B; et al. (2002). "Human immune associated nucleotide 1: a member of a new guanosine triphosphatase family expressed in resting T and B cells". Blood 99 (9): 3293–301. doi:10.1182/blood.V99.9.3293. PMID 11964296.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Scherer SW, Cheung J, MacDonald JR; et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Sandal T, Aumo L, Hedin L; et al. (2004). "Irod/Ian5: an inhibitor of gamma-radiation- and okadaic acid-induced apoptosis". Mol. Biol. Cell 14 (8): 3292–304. doi:10.1091/mbc.E02-10-0700. PMC 181568. PMID 12925764.
Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zenz T, Roessner A, Thomas A; et al. (2004). "hIan5: the human ortholog to the rat Ian4/Iddm1/lyp is a new member of the Ian family that is overexpressed in B-cell lymphoid malignancies". Genes Immun. 5 (2): 109–16. doi:10.1038/sj.gene.6364044. PMID 14724691.
Krücken J, Schroetel RM, Müller IU; et al. (2005). "Comparative analysis of the human gimap gene cluster encoding a novel GTPase family". Gene 341: 291–304. doi:10.1016/j.gene.2004.07.005. PMID 15474311.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Hellquist A, Zucchelli M, Kivinen K; et al. (2007). "The human GIMAP5 gene has a common polyadenylation polymorphism increasing risk to systemic lupus erythematosus". J. Med. Genet. 44 (5): 314–21. doi:10.1136/jmg.2006.046185. PMC 2597989. PMID 17220214.
Dalberg U, Markholst H, Hornum L (2007). "Both Gimap5 and the diabetogenic BBDP allele of Gimap5 induce apoptosis in T cells". Int. Immunol. 19 (4): 447–53. doi:10.1093/intimm/dxm009. PMID 17369194.
Shin JH, Janer M, McNeney B; et al. (2007). "IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5". Genes Immun. 8 (6): 503–12. doi:10.1038/sj.gene.6364413. PMID 17641683.

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GIMAP5

References

Further reading