GDF1
| Growth differentiation factor 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | GDF1 ; DORV; DTGA3; RAI | ||||||||||||
| External IDs | OMIM: 602880 MGI: 95683 HomoloGene: 105644 GeneCards: GDF1 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2657 | 14559 | |||||||||||
| Ensembl | ENSG00000223802 | ENSMUSG00000055694 | |||||||||||
| UniProt | P27539 | P20863 | |||||||||||
| RefSeq (mRNA) | NM_001492 | NM_001163282 | |||||||||||
| RefSeq (protein) | NP_001483 | NP_001156754 | |||||||||||
| Location (UCSC) |
Chr 19: 18.87 – 18.9 Mb |
Chr 8: 70.33 – 70.33 Mb | |||||||||||
| PubMed search | |||||||||||||
Growth differentiation factor-1 (GDF1) is a protein that in humans is encoded by the GDF1 gene.[1]
GDF1 belongs to the transforming growth factor beta superfamily that has a role in left-right patterning and mesoderm induction during embryonic development.[2] It is found in the brain, spinal cord and peripheral nerves of embryos.[1][2]
References
- 1 2 Lee SJ (May 1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.
- 1 2 Rankin CT, Bunton T, Lawler AM, Lee SJ (March 2000). "Regulation of left-right patterning in mice by growth/differentiation factor-1". Nat. Genet. 24 (3): 262–5. doi:10.1038/73472. PMID 10700179.
Further reading
- Jiang JC, Kirchman PA, Zagulski M; et al. (1998). "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human.". Genome Res. 8 (12): 1259–72. doi:10.1101/gr.8.12.1259. PMID 9872981.
- Lee SJ (1990). "Identification of a novel member (GDF-1) of the transforming growth factor-beta superfamily.". Mol. Endocrinol. 4 (7): 1034–40. doi:10.1210/mend-4-7-1034. PMID 1704486.
- Li J, Jia H, Xie L; et al. (2009). "Correlation of inhibitor of differentiation 1 expression to tumor progression, poor differentiation and aggressive behaviors in cervical carcinoma.". Gynecol. Oncol. 114 (1): 89–93. doi:10.1016/j.ygyno.2009.03.016. PMID 19359031.
- Ducy P, Karsenty G (2000). "The family of bone morphogenetic proteins.". Kidney Int. 57 (6): 2207–14. doi:10.1046/j.1523-1755.2000.00081.x. PMID 10844590.
- Lee SJ (1991). "Expression of growth/differentiation factor 1 in the nervous system: conservation of a bicistronic structure.". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4250–4. doi:10.1073/pnas.88.10.4250. PMC 51636. PMID 2034669.
- Roessler E, Pei W, Ouspenskaia MV; et al. (2009). "Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly.". Mol. Genet. Metab. 98 (1-2): 225–34. doi:10.1016/j.ymgme.2009.05.005. PMC 2774839. PMID 19553149.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Grimwood J, Gordon LA, Olsen A; et al. (2004). "The DNA sequence and biology of human chromosome 19.". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Karkera JD, Lee JS, Roessler E; et al. (2007). "Loss-of-function mutations in growth differentiation factor-1 (GDF1) are associated with congenital heart defects in humans.". Am. J. Hum. Genet. 81 (5): 987–94. doi:10.1086/522890. PMC 2265655. PMID 17924340.
- Polymeropoulos MH, Xiao H, Sikela JM; et al. (1993). "Chromosomal distribution of 320 genes from a brain cDNA library.". Nat. Genet. 4 (4): 381–6. doi:10.1038/ng0893-381. PMID 8401586.
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