GCAT

Glycine C-acetyltransferase
Identifiers
Symbols GCAT ; KBL
External IDs OMIM: 607422 HomoloGene: 8475 GeneCards: GCAT Gene
EC number 2.3.1.29
Orthologs
Species Human Mouse
Entrez 23464 26912
Ensembl ENSG00000100116 ENSMUSG00000006378
UniProt O75600 O88986
RefSeq (mRNA) NM_001171690 NM_001161712
RefSeq (protein) NP_001165161 NP_001155184
Location (UCSC) Chr 22:
37.81 – 37.82 Mb		 Chr 15:
79.03 – 79.04 Mb
PubMed search

Glycine C-acetyltransferase is a protein that in humans is encoded by the GCAT gene.[1]

Function

The degradation of L-threonine to glycine consists of a two-step biochemical pathway involving the enzymes L-threonine dehydrogenase and 2-amino-3-ketobutyrate coenzyme A ligase. L-Threonine is first converted into 2-amino-3-ketobutyrate by L-threonine dehydrogenase. This gene encodes the second enzyme in this pathway, which then catalyzes the reaction between 2-amino-3-ketobutyrate and coenzyme A to form glycine and acetyl-CoA. The encoded enzyme is considered a class II pyridoxal-phosphate-dependent aminotransferase. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 14.

References

  1. ↑ "Entrez Gene: Glycine C-acetyltransferase".

Further reading

  • Jacquot C, Lanco X, Carbonnelle D, Sevestre O, Tomasoni C, Briad G, Juget M, Roussis V, Roussakis C (2002). "Effect of four genes (ALDH1, NRF1, JAM and KBL) on proliferation arrest in a non-small cell bronchopulmonary cancer line". Anticancer Research 22 (4): 2229–35. PMID 12174908. 
  • Tressel T, Thompson R, Zieske LR, Menendez MI, Davis L (Dec 1986). "Interaction between L-threonine dehydrogenase and aminoacetone synthetase and mechanism of aminoacetone production". The Journal of Biological Chemistry 261 (35): 16428–37. PMID 3536927. 
  • Edgar AJ, Polak JM (Mar 2000). "Molecular cloning of the human and murine 2-amino-3-ketobutyrate coenzyme A ligase cDNAs". European Journal of Biochemistry / FEBS 267 (6): 1805–12. doi:10.1046/j.1432-1327.2000.01175.x. PMID 10712613. 
  • Hashizume, O., Ohnishi, S., Mito, T., Shimizu, A., Iashikawa, K., Nakada, K., ... & Hayashi, J. I. (2015). "Epigenetic regulation of the nuclear-coded GCAT and SHMT2 genes confers human age-associated mitochondrial respiration defects". Scientific Reports 5 (10434). doi:10.1038/srep10434. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.


This article is issued from Wikipedia - version of the Wednesday, February 10, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.