Follicular hyperplasia
Follicular hyperplasia (or "Reactive follicular hyperplasia" or "Lymphoid nodular hyperplasia") is a type of lymphoid hyperplasia. It is caused by a stimulation of the B cell compartment.[1] It is caused by an abnormal proliferation of secondary follicles and occurs principally in the cortex without broaching the lymph node capsule. The follicles are cytologically polymorphous, are often polarized, and vary in size and shape.[2] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles).
Causes
Some specific reactive lymphadenopathies with a predominantly follicular pattern:[3]
- Rheumatoid arthritis
- Sjogren syndrome
- IgG4-related disease (IgG4-related lymphadenopathy) [4]
- Kimura disease
- Toxoplasmosis
- Syphilis
- Castleman disease
- HIV-associated lymphadenopathy
- Progressive transformation of germinal centers (PTGC)
References
- ↑ Weiss, L. M.; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology. 26 Suppl 1: S88–96. doi:10.1038/modpathol.2012.176. PMID 23281438.
- ↑ Drew, Torigan et al. "Lymphoid hyperplasia of stomach". American Journal of Roentgenology. Retrieved 2 November 2012.
- ↑ Weiss, L. M.; O'Malley, D (2013). "Benign lymphadenopathies". Modern Pathology. 26 Suppl 1: S88–96. doi:10.1038/modpathol.2012.176. PMID 23281438.
- ↑ John H. Stone, Arezou Khosroshahi, Vikram Deshpande et al. (October 2012). "Recommendations for the nomenclature of IgG4-related disease and its individual organ system manifestations". Arthritis & Rheumatism 64 (10): 3061–3067. doi:10.1002/art.34593. PMID 22736240.
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