Fibrosarcoma

Fibrosarcoma
Micrograph of a tumour with the herringbone pattern as may be seen in fibrosarcoma. H&E stain.
Classification and external resources
Specialty	oncology
ICD-10	C49 (ILDS C49.M42)
ICD-O	M 8810/3
MeSH	D005354

Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. It is usually found in males aged 30 to 40 . It originates in fibrous tissues of the bone and invades long or flat bones such as femur, tibia, and mandible. It also involves periosteum and overlying muscle.

Pathology

The tumor may present different degrees of differentiation: low grade (differentiated), intermediate malignancy and high malignancy (anaplastic). Depending on this differentiation, tumour cells may resemble mature fibroblasts (spindle-shaped), secreting collagen, with rare mitoses. These cells are arranged in short fascicles which split and merge, giving the appearance of "fish bone" known as a herringbone pattern. Poorly differentiated tumors consist in more atypical cells, pleomorphic, giant cells, multinucleated, numerous atypical mitoses and reduced collagen production. Presence of immature blood vessels (sarcomatous vessels lacking endothelial cells) favors the bloodstream metastasizing.

Clinical presentation in humans

Adult-type

Individuals presenting with fibrosarcoma are usually adults aged thirty to fifty five years, often presenting with pain. In adults, males have a higher incidence for fibrosarcoma than females.

Infantile-type

In infants, fibrosarcoma is usually congenital. Infants presenting with fibrosarcoma usually do so in the first two years of their life.

Ancillary testing

Ancillary testing for fibrosarcoma includes IHC, where vimentin is positive, cytokeratin and S100 are negative, and actin is variable.

Fibrosarcoma in dogs and cats

Cat after 4th Fibrosarcoma OP

Fibrosarcoma occurs most frequently in the mouth in dogs . The tumor is locally invasive, and often recurs following surgery . Radiation therapy and chemotherapy are also used in treatment. Fibrosarcoma is also a rare bone tumor in dogs.^[1]

In cats, fibrosarcoma occurs on the skin. It is also the most common vaccine-associated sarcoma.^[1]

References

1 2 Ettinger, Stephen J.;Feldman, Edward C. (1995). Textbook of Veterinary Internal Medicine (4th ed.). W.B. Saunders Company. ISBN 0-7216-6795-3.

External links

Connective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)

Not otherwise specified

Connective tissue neoplasm

Fibromatous

Fibroma/fibrosarcoma:	Dermatofibrosarcoma protuberans Desmoplastic fibroma

Fibroma/fibromatosis:	Aggressive infantile fibromatosis Aponeurotic fibroma Collagenous fibroma Diffuse infantile fibromatosis Familial myxovascular fibromas Fibroma of tendon sheath Fibromatosis colli Infantile digital fibromatosis Juvenile hyaline fibromatosis Plantar fibromatosis Pleomorphic fibroma Oral submucous fibrosis

Histiocytoma/histiocytic sarcoma:	Benign fibrous histiocytoma Malignant fibrous histiocytoma Atypical fibroxanthoma Solitary fibrous tumor

Synovial-like

general:	Myoma/myosarcoma

smooth muscle:	Leiomyoma/leiomyosarcoma

skeletal muscle:	Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma Sarcoma botryoides Alveolar rhabdomyosarcoma

Leiomyoma Angioleiomyoma Angiolipoleiomyoma Genital leiomyoma Leiomyosarcoma Multiple cutaneous and uterine leiomyomatosis syndrome Multiple cutaneous leiomyoma Neural fibrolipoma Solitary cutaneous leiomyoma STUMP

Complex mixed and stromal

Mesothelial

Tumours of bone and cartilage (ICD-O 9180–9269) (C40–C41/D16, 170/213)

Diaphysis

Myeloid	Multiple myeloma

Epithelial	Adamantinoma

PNET/Ewing family	Ewing's sarcoma

Metaphysis

Osteoblast	Osteoid osteoma Osteoblastoma Osteoma/osteosarcoma

Chondroblast	Chondroma/ecchondroma/enchondroma Enchondromatosis Extraskeletal chondroma Chondrosarcoma Mesenchymal chondrosarcoma Myxoid chondrosarcoma Osteochondroma Osteochondromatosis Chondromyxoid fibroma

Fibrous	(Peripheral) Ossifying fibroma Fibrosarcoma

Epiphysis

Chondroblast	Chondroblastoma

Myeloid	Giant-cell tumor of bone

Other/ungrouped

Notochord	Chordoma

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