Festuclavine dehydrogenase

Festuclavine dehydrogenase (EC 1.5.1.44, FgaFS, festuclavine synthase) is an enzyme with system name festuclavine:NAD⁺ oxidoreductase.^[1] This enzyme catalyses the following chemical reaction

festuclavine + NAD⁺

\rightleftharpoons

6,8-dimethyl-6,7-didehydroergoline + NADH + H⁺

The enzyme takes part in the biosynthesis of fumigaclavine C.

References

↑ Wallwey, C., Matuschek, M., Xie, X.L. and Li, S.M. (2010). "Ergot alkaloid biosynthesis in Aspergillus fumigatus: Conversion of chanoclavine-I aldehyde to festuclavine by the festuclavine synthase FgaFS in the presence of the old yellow enzyme FgaOx3". Org. Biomol. Chem. 8 (15): 3500–3508. doi:10.1039/c003823g. PMID 20526482.

External links

Festuclavine dehydrogenase at the US National Library of Medicine Medical Subject Headings (MeSH)

Oxidoreductases: CH-NH (EC 1.5)

1.5.1: NAD or NADP acceptor	Dihydrofolate reductase Saccharopine dehydrogenase Methylenetetrahydrofolate reductase

1.5.3: oxygen acceptor	Dihydrobenzophenanthridine oxidase Sarcosine oxidase Proline oxidase

1.5.5: quinone acceptor	Electron-transferring-flavoprotein dehydrogenase

1.5.99	Sarcosine dehydrogenase

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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