FZD3

Frizzled class receptor 3

Identifiers

FZD3 ; Fz-3

External IDs

OMIM: 606143 MGI: 108476 HomoloGene: 23004 IUPHAR: 231 GeneCards: FZD3 Gene

Gene ontology
Molecular function	• G-protein coupled receptor activity • protein binding • Wnt-protein binding • PDZ domain binding • Wnt-activated receptor activity
Cellular component	• cytoplasm • plasma membrane • cell surface • integral component of membrane • apical plasma membrane • lateral plasma membrane • axon • dendrite • filopodium tip • neuronal cell body • presynaptic active zone
Biological process	• establishment of planar polarity • neuron migration • neural tube closure • hair follicle development • positive regulation of neuroblast proliferation • G-protein coupled receptor signaling pathway • neuron differentiation • cell proliferation in midbrain • non-canonical Wnt signaling pathway • post-anal tail morphogenesis • inner ear morphogenesis • negative regulation of mitotic cell cycle, embryonic • canonical Wnt signaling pathway • sympathetic ganglion development • commissural neuron axon guidance • negative regulation of execution phase of apoptosis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 8:
28.49 – 28.57 Mb

Chr 14:
65.2 – 65.26 Mb

PubMed search

Frizzled-3 is a protein that in humans is encoded by the FZD3 gene.^[1]^[2]^[3]

Function

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. It may play a role in mammalian hair follicle development.^[3]

The function of this gene is largely derived from mouse studies. Fzd3 in the mouse functions through planar cell polarity signaling instead of the canonical Wnt/beta-catenin pathway. Fzd3 controls axon growth and guidance in the mouse nervous system, and migration of neural crest cells.^[4]^[5]

References

↑ Kirikoshi H, Koike J, Sagara N, Saitoh T, Tokuhara M, Tanaka K, Sekihara H, Hirai M, Katoh M (Jun 2000). "Molecular cloning and genomic structure of human frizzled-3 at chromosome 8p21". Biochem Biophys Res Commun 271 (1): 8–14. doi:10.1006/bbrc.2000.2578. PMID 10777673.
↑ Sala CF, Formenti E, Terstappen GC, Caricasole A (Jul 2000). "Identification, gene structure, and expression of human frizzled-3 (FZD3)". Biochem Biophys Res Commun 273 (1): 27–34. doi:10.1006/bbrc.2000.2882. PMID 10873558.
1 2 "Entrez Gene: FZD3 frizzled homolog 3 (Drosophila)".
↑ Hua ZL, Smallwood PM, Nathans J (Dec 2013). "Frizzled3 controls axonal development in distinct populations of cranial and spinal motor neurons". eLife 2: e01482. doi:10.7554/eLife.01482. PMC 3865743. PMID 24347548.
↑ Hua ZL, Jeon S, Caterina MJ, Nathans J (Jul 2014). "Frizzled3 is required for the development of multiple axon tracts in the mouse central nervous system". Proc Natl Acad Sci U S A 111 (29): E3005–14. doi:10.1073/pnas.1406399111. PMC 4115534. PMID 24799694.

External links

"Frizzled Receptors: FZD₃". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin like

Neurotransmitter

Adrenergic	α1 (A B D) α2 (A B C) β1 β2 β3

Purinergic	Adenosine (A1 A2A A2B A3) P2Y (1 2 4 5 6 8 9 10 11 12 13 14)

Serotonin	(all but 5-HT3) 5-HT1 (A B D E F) 5-HT2 (A B C) 5-HT (4 5A 6 7)

Other	Acetylcholine (M1 M2 M3 M4 M5) Dopamine (D1 D2 D3 D4 D5) Histamine (H1 H2 H3 H4) Melatonin (1A 1B 1C) TAAR (1 2 3 5 6 8 9)

Metabolites and
signaling molecules

Eicosanoid	CysLT (1 2) LTB4 (1 2) FPRL1 OXE Prostaglandin (DP (1 2), EP (1 2 3 4), FP) Prostacyclin Thromboxane

Other	Bile acid Cannabinoid (CB1 CB2, GPR (18 55 119)) EBI2 Estrogen Free fatty acid (1 2 3 4) Lactate Lysophosphatidic acid (1 2 3 4 5 6) Lysophospholipid (1 2 3 4 5 6 7 8) Niacin (1 2) Oxoglutarate PAF Sphingosine-1-phosphate (1 2 3 4 5) Succinate

Peptide

Neuropeptide	B/W (1 2) FF (1 2) S Y (1 2 4 5) Neuromedin (B U (1 2)) Neurotensin (1 2)

Other	Anaphylatoxin (C3a C5a) Angiotensin (1 2) Apelin Bombesin (BRS3 GRPR NMBR) Bradykinin (B1 B2) Chemokine Cholecystokinin (A B) Endothelin (A B) Formyl peptide (1 2 3) FSH Galanin (1 2 3) GHB receptor Gonadotropin-releasing hormone (1 2) Ghrelin Kisspeptin Luteinizing hormone/choriogonadotropin MAS (1 1L D E F G X1 X2 X3 X4) Melanocortin (1 2 3 4 5) MCHR (1 2) Motilin Opioid (Delta Kappa Mu Nociceptin & Zeta, but not Sigma) Orexin (1 2) Oxytocin Prokineticin (1 2) Prolactin-releasing peptide Relaxin (1 2 3 4) Somatostatin (1 2 3 4 5) Tachykinin (1 2 3) Thyrotropin Thyrotropin-releasing hormone Urotensin-II Vasopressin (1A 1B 2)

Miscellaneous

Orphan	GPR (1 3 4 6 12 15 17 18 19 20 21 22 23 25 26 27 31 32 33 34 35 37 39 42 44 45 50 52 55 61 62 63 65 68 75 77 78 81 82 83 84 85 87 88 92 101 103 109A 109B 119 120 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183)

Other	Adrenomedullin Olfactory Opsin (3 4 5 1LW 1MW 1SW RGR RRH) Protease-activated (1 2 3 4) SREB (1 2 3)

Class B: Secretin like

Adhesion	ADGRG (1 2 3 4 5 6 7)

Orphan	GPR (56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157)

Other	Brain-specific angiogenesis inhibitor (1 2 3) Cadherin (1 2 3) Calcitonin CALCRL CD97 Corticotropin-releasing hormone (1 2) EMR (1 2 3) Glucagon (GR GIPR GLP1R GLP2R) Growth hormone releasing hormone PACAPR1 GPR Latrophilin (1 2 3 ELTD1) Methuselah-like proteins Parathyroid hormone (1 2) Secretin Vasoactive intestinal peptide (1 2)

Class C: Metabotropic glutamate / pheromone

Taste	TAS1R (1 2 3) TAS2R (1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60)

Other	Calcium-sensing receptor GABA B (1 2) Glutamate receptor (Metabotropic glutamate (1 2 3 4 5 6 7 8)) GPRC6A GPR (156 158 179) RAIG (1 2 3 4)

Class F: Frizzled / Smoothened

Frizzled	Frizzled (1 2 3 4 5 6 7 8 9 10)

Smoothened	Smoothened

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FZD3

Function

See also

References

Further reading

External links