FUT8
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.[1][2]
This enzyme belongs to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternatively spliced variants encoding different isoforms have been identified.[2]
References
- ↑ Costache M, Apoil PA, Cailleau A, Elmgren A, Larson G, Henry S, Blancher A, Iordachescu D, Oriol R, Mollicone R (Dec 1997). "Evolution of fucosyltransferase genes in vertebrates". J Biol Chem 272 (47): 29721–8. doi:10.1074/jbc.272.47.29721. PMID 9368041.
- 1 2 "Entrez Gene: FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)".
Further reading
- Miyoshi E, Noda K, Yamaguchi Y; et al. (2000). "The alpha1-6-fucosyltransferase gene and its biological significance.". Biochim. Biophys. Acta 1473 (1): 9–20. doi:10.1016/s0304-4165(99)00166-x. PMID 10580126.
- Kalyanaraman VS, Rodriguez V, Veronese F; et al. (1990). "Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.". AIDS Res. Hum. Retroviruses 6 (3): 371–80. doi:10.1089/aid.1990.6.371. PMID 2187500.
- Pal R, Hoke GM, Sarngadharan MG (1989). "Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3384–8. doi:10.1073/pnas.86.9.3384. PMC 287137. PMID 2541446.
- Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP (1989). "Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.". J. Virol. 63 (6): 2452–6. PMC 250699. PMID 2542563.
- Kozarsky K, Penman M, Basiripour L; et al. (1989). "Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein.". J. Acquir. Immune Defic. Syndr. 2 (2): 163–9. PMID 2649653.
- Robinson WE, Montefiori DC, Mitchell WM (1988). "Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.". AIDS Res. Hum. Retroviruses 3 (3): 265–82. doi:10.1089/aid.1987.3.265. PMID 2829950.
- Andersson B, Wentland MA, Ricafrente JY; et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
- Yu W, Andersson B, Worley KC; et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
- Yanagidani S, Uozumi N, Ihara Y; et al. (1997). "Purification and cDNA cloning of GDP-L-Fuc:N-acetyl-beta-D-glucosaminide:alpha1-6 fucosyltransferase (alpha1-6 FucT) from human gastric cancer MKN45 cells.". J. Biochem. 121 (3): 626–32. doi:10.1093/oxfordjournals.jbchem.a021631. PMID 9133635.
- Yamaguchi Y, Fujii J, Inoue S; et al. (1999). "Mapping of the alpha-1,6-fucosyltransferase gene, FUT8, to human chromosome 14q24.3.". Cytogenet. Cell Genet. 84 (1–2): 58–60. doi:10.1159/000015215. PMID 10343104.
- Takahashi T, Ikeda Y, Tateishi A; et al. (2000). "A sequence motif involved in the donor substrate binding by alpha1,6-fucosyltransferase: the role of the conserved arginine residues.". Glycobiology 10 (5): 503–10. doi:10.1093/glycob/10.5.503. PMID 10764839.
- Yamaguchi Y, Ikeda Y, Takahashi T; et al. (2000). "Genomic structure and promoter analysis of the human alpha1, 6-fucosyltransferase gene (FUT8).". Glycobiology 10 (6): 637–43. doi:10.1093/glycob/10.6.637. PMID 10814706.
- Takahashi T, Ikeda Y, Miyoshi E; et al. (2000). "alpha1,6fucosyltransferase is highly and specifically expressed in human ovarian serous adenocarcinomas.". Int. J. Cancer 88 (6): 914–9. doi:10.1002/1097-0215(20001215)88:6<914::AID-IJC12>3.0.CO;2-1. PMID 11093814.
- Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism.". J. Biol. Chem. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
- Coullin P, Crooijmans RP, Groenen MA; et al. (2003). "Assignment of FUT8 to chicken chromosome band 5q1.4 and to human chromosome 14q23.2→q24.1 by in situ hybridization. Conserved and compared synteny between human and chicken.". Cytogenet. Genome Res. 97 (3–4): 234–8. doi:10.1159/000066611. PMID 12438718.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Martinez-Duncker I, Michalski JC, Bauvy C; et al. (2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.". Glycobiology 14 (1): 13–25. doi:10.1093/glycob/cwh006. PMID 14514715.
- Ito Y, Miyauchi A, Yoshida H; et al. (2003). "Expression of alpha1,6-fucosyltransferase (FUT8) in papillary carcinoma of the thyroid: its linkage to biological aggressiveness and anaplastic transformation.". Cancer Lett. 200 (2): 167–72. doi:10.1016/S0304-3835(03)00383-5. PMID 14568171.
PDB gallery |
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| | 2de0: Crystal structure of human alpha 1,6-fucosyltransferase, FUT8 |
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