FSTL1
| Follistatin-like 1 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | FSTL1 ; FRP; FSL1; MIR198 | ||||||||||||
| External IDs | OMIM: 605547 MGI: 102793 HomoloGene: 5144 GeneCards: FSTL1 Gene | ||||||||||||
| |||||||||||||
| RNA expression pattern | |||||||||||||
 | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 11167 | 14314 | |||||||||||
| Ensembl | ENSG00000163430 | ENSMUSG00000022816 | |||||||||||
| UniProt | Q12841 | Q62356 | |||||||||||
| RefSeq (mRNA) | NM_007085 | NM_008047 | |||||||||||
| RefSeq (protein) | NP_009016 | NP_032073 | |||||||||||
| Location (UCSC) |
Chr 3: 120.39 – 120.45 Mb |
Chr 16: 37.78 – 37.84 Mb | |||||||||||
| PubMed search | |||||||||||||
Follistatin-related protein 1 is a protein that in humans is encoded by the FSTL1 gene.[1][2][3]
Structure
This gene encodes a protein with similarity to follistatin, an BMP-4-binding protein.[4] It binds to BMP-4 and TGF-β1, but not Activin A.[4] It contains an FS module (a follistatin-like sequence containing 10 conserved cysteine residues), a Kazal-type serine protease inhibitor domain, 2 EF hand domains, and a Von Willebrand factor type C domain.[3]
Clinical significance
Development
FSTL1 has a role in development,[5][6] such as lung development,[4][7] ureter development,[8] central nervous system development,[9] and skeletal development.[7]
Arthritis
This gene product is thought to be an autoantigen associated with rheumatoid arthritis.[3]
FSTL1 up-regulates proinflammatory mediators important in the pathology of arthritis, and serum levels of FSTL1 correlate with severity of arthritis.[10][11][12]
Cardiovascular diseases
FSTL1 protein seems to have a cardioprotective role. FSTL1 attenuated hypertrophy following pressure overload[13] and prevented myocardial ischemia/reperfusion injury in a mouse or pig model of ischemia/reperfusion.[14] Muscle-derived Fstl1 modulates vascular remodelling in response to injury.[15]
References
- ↑ Zwijsen A, Blockx H, Van Arnhem W, Willems J, Fransen L, Devos K, Raymackers J, Van de Voorde A, Slegers H (Nov 1994). "Characterization of a rat C6 glioma-secreted follistatin-related protein (FRP). Cloning and sequence of the human homologue". European Journal of Biochemistry / FEBS 225 (3): 937–46. doi:10.1111/j.1432-1033.1994.0937b.x. PMID 7957230.
- ↑ Tanaka M, Ozaki S, Osakada F, Mori K, Okubo M, Nakao K (Sep 1998). "Cloning of follistatin-related protein as a novel autoantigen in systemic rheumatic diseases". International Immunology 10 (9): 1305–14. doi:10.1093/intimm/10.9.1305. PMID 9786430.
- 1 2 3 "Entrez Gene: FSTL1 follistatin-like 1".
- 1 2 3 Geng Y, Dong Y, Yu M, Zhang L, Yan X, Sun J, Qiao L, Geng H, Nakajima M, Furuichi T, Ikegawa S, Gao X, Chen YG, Jiang D, Ning W (Apr 2011). "Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development". Proceedings of the National Academy of Sciences of the United States of America 108 (17): 7058–63. doi:10.1073/pnas.1007293108. PMID 21482757.
- ↑ Umezu T, Yamanouchi H, Iida Y, Miura M, Tomooka Y (Mar 2010). "Follistatin-like-1, a diffusible mesenchymal factor determines the fate of epithelium". Proceedings of the National Academy of Sciences of the United States of America 107 (10): 4601–6. doi:10.1073/pnas.0909501107. PMID 20176958.
- ↑ Sylva M, Moorman AF, van den Hoff MJ (Mar 2013). "Follistatin-like 1 in vertebrate development". Birth Defects Research. Part C, Embryo Today 99 (1): 61–9. doi:10.1002/bdrc.21030. PMID 23723173.
- 1 2 Sylva M, Li VS, Buffing AA, van Es JH, van den Born M, van der Velden S, Gunst Q, Koolstra JH, Moorman AF, Clevers H, van den Hoff MJ (3 August 2011). "The BMP antagonist follistatin-like 1 is required for skeletal and lung organogenesis". PLOS ONE 6 (8): e22616. doi:10.1371/journal.pone.0022616. PMID 21826198.
- ↑ Xu J, Qi X, Gong J, Yu M, Zhang F, Sha H, Gao X (2012). "Fstl1 antagonizes BMP signaling and regulates ureter development". PLOS ONE 7 (4): e32554. doi:10.1371/journal.pone.0032554. PMID 22485132.
- ↑ Yang Y, Liu J, Mao H, Hu YA, Yan Y, Zhao C (Oct 2009). "The expression pattern of Follistatin-like 1 in mouse central nervous system development". Gene Expression Patterns 9 (7): 532–40. doi:10.1016/j.gep.2009.07.001. PMID 19595790.
- ↑ Chaly Y, Marinov AD, Oxburgh L, Bushnell DS, Hirsch R (Apr 2012). "FSTL1 promotes arthritis in mice by enhancing inflammatory cytokine/chemokine expression". Arthritis and Rheumatism 64 (4): 1082–8. doi:10.1002/art.33422. PMC 3276726. PMID 22006268.
- ↑ Chaly Y, Blair HC, Smith SM, Bushnell DS, Marinov AD, Campfield BT, Hirsch R (Jul 2015). "Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells". Annals of the Rheumatic Diseases 74 (7): 1467–73. doi:10.1136/annrheumdis-2013-204822. PMID 24641944.
- ↑ Chaly Y, Fu Y, Marinov A, Hostager B, Yan W, Campfield B, Kellum JA, Bushnell D, Wang Y, Vockley J, Hirsch R (May 2014). "Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages". European Journal of Immunology 44 (5): 1467–79. doi:10.1002/eji.201344063. PMID 24470197.
- ↑ Shimano M, Ouchi N, Nakamura K, van Wijk B, Ohashi K, Asaumi Y, Higuchi A, Pimentel DR, Sam F, Murohara T, van den Hoff MJ, Walsh K (Oct 2011). "Cardiac myocyte follistatin-like 1 functions to attenuate hypertrophy following pressure overload". Proceedings of the National Academy of Sciences of the United States of America 108 (43): E899–906. doi:10.1073/pnas.1108559108. PMID 21987816.
- ↑ Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T (Oct 2012). "Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models". Circulation 126 (14): 1728–38. doi:10.1161/CIRCULATIONAHA. PMID 22929303.
- ↑ Miyabe M, Ohashi K, Shibata R, Uemura Y, Ogura Y, Yuasa D, Kambara T, Kataoka Y, Yamamoto T, Matsuo K, Joki Y, Enomoto T, Hayakawa S, Hiramatsu-Ito M, Ito M, Van Den Hoff MJ, Walsh K, Murohara T, Ouchi N (Jul 2014). "Muscle-derived follistatin-like 1 functions to reduce neointimal formation after vascular injury". Cardiovascular Research 103 (1): 111–20. doi:10.1093/cvr/cvu105. PMID 24743592.
Further reading
- Vertegaal AC, Kuiperij HB, van Laar T, Scharnhorst V, van der Eb AJ, Zantema A (Dec 2000). "cDNA micro array identification of a gene differentially expressed in adenovirus type 5- versus type 12-transformed cells". FEBS Letters 487 (2): 151–5. doi:10.1016/S0014-5793(00)02339-5. PMID 11150499.
- Ciarmela P, Florio P, Sigurdardottir M, Toti P, Maguer-Satta V, Rimokh R, Altomare A, Tosi P, Petraglia F (Aug 2004). "Follistatin-related gene expression, but not follistatin expression, is decreased in human endometrial adenocarcinoma". European Journal of Endocrinology / European Federation of Endocrine Societies 151 (2): 251–7. doi:10.1530/eje.0.1510251. PMID 15296481.
- Zhang Z, Henzel WJ (Oct 2004). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Science 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
- Ehara Y, Sakurai D, Tsuchiya N, Nakano K, Tanaka Y, Yamaguchi A, Tokunaga K (2005). "Follistatin-related protein gene (FRP) is expressed in the synovial tissues of rheumatoid arthritis, but its polymorphisms are not associated with genetic susceptibility". Clinical and Experimental Rheumatology 22 (6): 707–12. PMID 15638044.
- Liu S, Wang L, Wang W, Lin J, Han J, Sun H, Guo H, Sun R, Wu Q (Apr 2006). "TSC-36/FRP inhibits vascular smooth muscle cell proliferation and migration". Experimental and Molecular Pathology 80 (2): 132–40. doi:10.1016/j.yexmp.2005.07.005. PMID 16256108.
- Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
This article is issued from Wikipedia - version of the Sunday, January 24, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.