FOXJ1
Forkhead box protein J1 is a protein that in humans is encoded by the FOXJ1 gene.[1] It has been shown that this gene is a transcription factor involved in ciliogenesis.[2]
Function
This gene encodes a member of the forkhead family of transcription factors. Similar genes in zebrafish and mouse have been shown to regulate the transcription of genes that control the production of motile cilia. The mouse ortholog also functions in the determination of left-right asymmetry.[1]
Clinical significance
Polymorphisms in this gene are associated with systemic lupus erythematosus and allergic rhinitis.[1]
References
- 1 2 3 "Entrez Gene: forkhead box J1".
- ↑ Yu X, Ng CP, Habacher H, Roy S (December 2008). "Foxj1 transcription factors are master regulators of the motile ciliogenic program". Nat. Genet. 40 (12): 1445–53. doi:10.1038/ng.263. PMID 19011630.
Further reading
- Li CS, Zhang Q, Lim MK; et al. (2007). "Association of FOXJ1 polymorphisms with systemic lupus erythematosus and rheumatoid arthritis in Korean population.". Experimental & Molecular Medicine 39 (6): 805–11. doi:10.1038/emm.2007.87. PMID 18160851.
- Li CS, Chae SC, Lee JH; et al. (2006). "Identification of single nucleotide polymorphisms in FOXJ1 and their association with allergic rhinitis.". J. Hum. Genet. 51 (4): 292–7. doi:10.1007/s10038-006-0359-8. PMID 16518568.
- Turner J, Roger J, Fitau J; et al. (2011). "Goblet cells are derived from a FOXJ1-expressing progenitor in a human airway epithelium.". Am. J. Respir. Cell Mol. Biol. 44 (3): 276–84. doi:10.1165/rcmb.2009-0304OC. PMID 20539013.
- Murphy DB, Seemann S, Wiese S; et al. (1997). "The human hepatocyte nuclear factor 3/fork head gene FKHL13: genomic structure and pattern of expression.". Genomics 40 (3): 462–9. doi:10.1006/geno.1996.4587. PMID 9073514.
- Maiti AK, Bartoloni L, Mitchison HM; et al. (2000). "No deleterious mutations in the FOXJ1 (alias HFH-4) gene in patients with primary ciliary dyskinesia (PCD).". Cytogenet. Cell Genet. 90 (1-2): 119–22. doi:10.1159/000015645. PMID 11060460.
- LeSimple P, van Seuningen I, Buisine MP; et al. (2007). "Trefoil factor family 3 peptide promotes human airway epithelial ciliated cell differentiation.". Am. J. Respir. Cell Mol. Biol. 36 (3): 296–303. doi:10.1165/rcmb.2006-0270OC. PMID 17008636.
- Lim L, Zhou H, Costa RH (1997). "The winged helix transcription factor HFH-4 is expressed during choroid plexus epithelial development in the mouse embryo.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3094–9. doi:10.1073/pnas.94.7.3094. PMC 20327. PMID 9096351.
- Pelletier GJ, Brody SL, Liapis H; et al. (1998). "A human forkhead/winged-helix transcription factor expressed in developing pulmonary and renal epithelium.". Am. J. Physiol. 274 (3 Pt 1): L351–9. PMID 9530170.
- Wu C, Ma MH, Brown KR; et al. (2007). "Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.". Proteomics 7 (11): 1775–85. doi:10.1002/pmic.200601006. PMID 17474147.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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