Forkhead box d1
Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene. [1]
Function
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014]. ##Evidence-Data-START## Transcript is intronless :: U59832.1 [ECO:0000345] ##Evidence-Data-END##
References
- ↑ "Entrez Gene: Forkhead box D1". Retrieved 2014-09-11.
Further reading
- Berg, D. T.; Myers, L. J.; Richardson, M. A.; Sandusky, G; Grinnell, B. W. (2005). "Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta". Journal of Biological Chemistry 280 (15): 14943–7. doi:10.1074/jbc.C400579200. PMID 15716278.
- Ernstsson, S; Pierrou, S; Hulander, M; Cederberg, A; Hellqvist, M; Carlsson, P; Enerbäck, S (1996). "Characterization of the human forkhead gene FREAC-4. Evidence for regulation by Wilms' tumor suppressor gene (WT-1) and p53". The Journal of Biological Chemistry 271 (35): 21094–9. doi:10.1074/jbc.271.35.21094. PMID 8702877.
- Schmitt, C; Ghazi, B; Bellier, F; Bensussan, A (2009). "Identification and analysis of the human CD160 promoter: Implication of a potential AML-1 binding site in promoter activation". Genes and Immunity 10 (7): 616–23. doi:10.1038/gene.2009.52. PMID 19626042.
- Thackray, V. G. (2014). "Fox tales: Regulation of gonadotropin gene expression by forkhead transcription factors". Molecular and Cellular Endocrinology 385 (1–2): 62–70. doi:10.1016/j.mce.2013.09.034. PMC 3947687. PMID 24099863.
- Lin, L; Peng, S. L. (2006). "Coordination of NF-kappaB and NFAT antagonism by the forkhead transcription factor Foxd1". Journal of immunology (Baltimore, Md. : 1950) 176 (8): 4793–803. doi:10.4049/jimmunol.176.8.4793. PMID 16585573.
- Larsson, C.; Hellqvist, M.; Pierrou, S.; White, I.; Enerbäck, S.; Carlsson, P. (1995). "Chromosomal Localization of Six Human Forkhead Genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)". Genomics 30 (3): 464–469. doi:10.1006/geno.1995.1266. PMID 8825632.
- Pierrou, S.; Hellqvist, M.; Samuelsson, L.; Enerbäck, S.; Carlsson, P. (1994). "Cloning and characterization of seven human forkhead proteins: Binding site specificity and DNA bending". The EMBO Journal 13 (20): 5002–5012. PMC 395442. PMID 7957066.
- Katoh, M; Katoh, M (2004). "Human FOX gene family (Review)". International journal of oncology 25 (5): 1495–500. doi:10.3892/ijo.25.5.1495. PMID 15492844.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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