Forkhead box C1

Forkhead box C1
PDB rendering based on 1d5v.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1d5v​
Identifiers
Symbols	FOXC1 ; ARA; FKHL7; FREAC-3; FREAC3; IGDA; IHG1; IRID1; RIEG3
External IDs	OMIM: 601090 MGI: 1347466 HomoloGene: 20373 GeneCards: FOXC1 Gene
Gene ontology Molecular function • RNA polymerase II regulatory region sequence-specific DNA binding • RNA polymerase II transcription factor activity, sequence-specific DNA binding • transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding • DNA binding • transcription factor activity, sequence-specific DNA binding • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding • protein binding • transcription factor binding • DNA binding, bending • sequence-specific DNA binding • transcription regulatory region DNA binding Cellular component • nucleus • nucleoplasm • nuclear heterochromatin • cytoplasm Biological process • skeletal system development • ossification • ovarian follicle development • eye development • ureteric bud development • in utero embryonic development • somitogenesis • lymph vessel development • blood vessel remodeling • regulation of transcription, DNA-templated • transcription from RNA polymerase II promoter • Notch signaling pathway • brain development • heart development • cell proliferation • germ cell migration • mesenchymal cell development • neural crest cell development • cell migration • negative regulation of angiogenesis • cell differentiation • collagen fibril organization • glycosaminoglycan metabolic process • lacrimal gland development • embryonic heart tube development • maintenance of lens transparency • vascular endothelial growth factor signaling pathway • odontogenesis of dentin-containing tooth • camera-type eye development • positive regulation of transcription, DNA-templated • negative regulation of mitotic cell cycle • positive regulation of transcription from RNA polymerase II promoter • regulation of organ growth • vascular endothelial growth factor receptor signaling pathway • paraxial mesoderm formation • artery morphogenesis • regulation of blood vessel size • ventricular cardiac muscle tissue morphogenesis • cardiac muscle cell proliferation • negative regulation of lymphangiogenesis • positive regulation of hematopoietic progenitor cell differentiation • positive regulation of hematopoietic stem cell differentiation • negative regulation of apoptotic process involved in outflow tract morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	2296	17300
Ensembl	ENSG00000054598	ENSMUSG00000050295
UniProt	Q12948	Q61572
RefSeq (mRNA)	NM_001453	NM_008592
RefSeq (protein)	NP_001444	NP_032618
Location (UCSC)	Chr 6: 1.61 – 1.61 Mb	Chr 13: 31.81 – 31.81 Mb
PubMed search

Forkhead box C1, also known as FOXC1, is a protein which in humans is encoded by the FOXC1 gene.^[1][2][3]

Function

This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding fork head domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly.^[1]

See also

• FOX proteins

References

Further reading

External links

• FOXC1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

PDB gallery 1d5v: SOLUTION STRUCTURE OF THE FORKHEAD DOMAIN OF THE ADIPOCYTE-TRANSCRIPTION FACTOR FREAC-11 (S12)