FCRL4
| Fc receptor-like 4 | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||||
| Symbols | FCRL4 ; CD307d; FCRH4; IGFP2; IRTA1 | ||||||||||||
| External IDs | OMIM: 605876 HomoloGene: 88926 GeneCards: FCRL4 Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 83417 | n/a | |||||||||||
| Ensembl | ENSG00000163518 | n/a | |||||||||||
| UniProt | Q96PJ5 | n/a | |||||||||||
| RefSeq (mRNA) | NM_031282 | n/a | |||||||||||
| RefSeq (protein) | NP_112572 | n/a | |||||||||||
| Location (UCSC) |
Chr 1: 157.57 – 157.6 Mb | n/a | |||||||||||
| PubMed search | n/a | ||||||||||||
Fc receptor-like protein 4 is a protein that in humans is encoded by the FCRL4 gene. FCRL4 is an inhibitory receptor expressed on human memory B cells which resides in epithelial tissues. [1][2][3]
References
- ↑ Hatzivassiliou G, Miller I, Takizawa J, Palanisamy N, Rao PH, Iida S, Tagawa S, Taniwaki M, Russo J, Neri A, Cattoretti G, Clynes R, Mendelsohn C, Chaganti RS, Dalla-Favera R (Apr 2001). "IRTA1 and IRTA2, novel immunoglobulin superfamily receptors expressed in B cells and involved in chromosome 1q21 abnormalities in B cell malignancy". Immunity 14 (3): 277–89. doi:10.1016/S1074-7613(01)00109-1. PMID 11290337.
- ↑ Davis RS, Wang YH, Kubagawa H, Cooper MD (Aug 2001). "Identification of a family of Fc receptor homologs with preferential B cell expression". Proc Natl Acad Sci U S A 98 (17): 9772–7. doi:10.1073/pnas.171308498. PMC 55528. PMID 11493702.
- ↑ "Entrez Gene: FCRL4 Fc receptor-like 4".
Further reading
- Taylor AI, Gould HJ, Sutton BJ, Calvert RA (2007). "The first avian Ig-like Fc receptor family member combines features of mammalian FcR and FCRL". Immunogenetics 59 (4): 323–8. doi:10.1007/s00251-007-0195-9. PMID 17273841.
- Ehrhardt GR, Hsu JT, Gartland L; et al. (2005). "Expression of the immunoregulatory molecule FcRH4 defines a distinctive tissue-based population of memory B cells". J. Exp. Med. 202 (6): 783–91. doi:10.1084/jem.20050879. PMC 2212938. PMID 16157685.
- Jöhrens K, Shimizu Y, Anagnostopoulos I; et al. (2006). "T-bet-positive and IRTA1-positive monocytoid B cells differ from marginal zone B cells and epithelial-associated B cells in their antigen profile and topographical distribution". Haematologica 90 (8): 1070–7. PMID 16079106.
- Falini B, Tiacci E, Pucciarini A; et al. (2004). "Expression of the IRTA1 receptor identifies intraepithelial and subepithelial marginal zone B cells of the mucosa-associated lymphoid tissue (MALT)". Blood 102 (10): 3684–92. doi:10.1182/blood-2003-03-0750. PMID 12881317.
- Guselnikov SV, Ershova SA, Mechetina LV; et al. (2002). "A family of highly diverse human and mouse genes structurally links leukocyte FcR, gp42 and PECAM-1". Immunogenetics 54 (2): 87–95. doi:10.1007/s00251-002-0436-x. PMID 12037601.
- Miller I, Hatzivassiliou G, Cattoretti G; et al. (2002). "IRTAs: a new family of immunoglobulinlike receptors differentially expressed in B cells". Blood 99 (8): 2662–9. doi:10.1182/blood.V99.8.2662. PMID 11929751.
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