FCGR1A

Fc fragment of IgG, high affinity Ia, receptor (CD64)

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3RJD, 4W4O, 4X4M

Identifiers

Symbols

FCGR1A ; CD64; CD64A; FCRI; IGFR1

External IDs

OMIM: 146760 MGI: 95498 HomoloGene: 475 ChEMBL: 5349 GeneCards: FCGR1A Gene

Gene ontology
Molecular function	• receptor signaling protein activity • protein binding • IgG binding
Cellular component	• plasma membrane • integral component of membrane • clathrin-coated endocytic vesicle membrane • early endosome membrane
Biological process	• antigen processing and presentation of peptide antigen via MHC class I • antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent • phagocytosis, engulfment • immune response • signal transduction • cytokine-mediated signaling pathway • intracellular signal transduction • Fc-gamma receptor signaling pathway involved in phagocytosis • antigen processing and presentation of exogenous peptide antigen via MHC class I • innate immune response • interferon-gamma-mediated signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
149.78 – 149.79 Mb

Chr 3:
96.28 – 96.29 Mb

PubMed search

High affinity immunoglobulin gamma Fc receptor I is a protein that in humans is encoded by the FCGR1A gene.^[1]^[2]^[3]

Interactions

FCGR1A has been shown to interact with FCAR.^[4] The FcgRI binds the Fc portion of IgG and causes activation of the host cell via an intercellular ITAM motif. ^[5]

References

↑ Maresco DL, Chang E, Theil KS, Francke U, Anderson CL (September 1996). "The three genes of the human FCGR1 gene family encoding Fc gamma RI flank the centromere of chromosome 1 at 1p12 and 1q21". Cytogenetics and Cell Genetics 73 (3): 157–63. doi:10.1159/000134330. PMID 8697799.
↑ Maresco DL, Blue LE, Culley LL, Kimberly RP, Anderson CL, Theil KS (November 1998). "Localization of FCGR1 encoding Fcgamma receptor class I in primates: molecular evidence for two pericentric inversions during the evolution of human chromosome 1". Cytogenetics and Cell Genetics 82 (1-2): 71–4. doi:10.1159/000015067. PMID 9763663.
↑ "Entrez Gene: FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64)".
↑ Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
↑ The function of Fcγ receptors in dendritic cells and macrophages Martin Guilliams Pierre Bruhns Yvan Saeys Hamida Hammad and Bart N. Lambrecht FEBRUARY 2014 | VOLUME 14 Nature Reviews Immunology

Monteiro RC, Van De Winkel JG (2003). "IgA Fc receptors". Annual Review of Immunology 21: 177–204. doi:10.1146/annurev.immunol.21.120601.141011. PMID 12524384.
Ernst LK, van de Winkel JG, Chiu IM, Anderson CL (Aug 1992). "Three genes for the human high affinity Fc receptor for IgG (Fc gamma RI) encode four distinct transcription products". The Journal of Biological Chemistry 267 (22): 15692–700. PMID 1379234.
Benech PD, Sastry K, Iyer RR, Eichbaum QG, Raveh DP, Ezekowitz RA (Oct 1992). "Definition of interferon gamma-response elements in a novel human Fc gamma receptor gene (Fc gamma RIb) and characterization of the gene structure". The Journal of Experimental Medicine 176 (4): 1115–23. doi:10.1084/jem.176.4.1115. PMC 2119393. PMID 1402657.
Porges AJ, Redecha PB, Doebele R, Pan LC, Salmon JE, Kimberly RP (Nov 1992). "Novel Fc gamma receptor I family gene products in human mononuclear cells". The Journal of Clinical Investigation 90 (5): 2102–9. doi:10.1172/JCI116094. PMC 443278. PMID 1430234.
van de Winkel JG, Ernst LK, Anderson CL, Chiu IM (Jul 1991). "Gene organization of the human high affinity receptor for IgG, Fc gamma RI (CD64). Characterization and evidence for a second gene". The Journal of Biological Chemistry 266 (20): 13449–55. PMID 1830050.
Eizuru Y, Minamishima Y (1989). "Induction of Fc (IgG) receptor(s) by simian cytomegaloviruses in human embryonic lung fibroblasts". Intervirology 29 (6): 339–45. PMID 2852656.
Allen JM, Seed B (Jan 1989). "Isolation and expression of functional high-affinity Fc receptor complementary DNAs". Science 243 (4889): 378–81. doi:10.1126/science.2911749. PMID 2911749.
Allen JM, Seed B (Dec 1988). "Nucleotide sequence of three cDNAs for the human high affinity Fc receptor (FcRI)". Nucleic Acids Research 16 (24): 11824. doi:10.1093/nar/16.24.11824. PMC 339124. PMID 2974947.
Indik ZK, Hunter S, Huang MM, Pan XQ, Chien P, Kelly C, Levinson AI, Kimberly RP, Schreiber AD (Jul 1994). "The high affinity Fc gamma receptor (CD64) induces phagocytosis in the absence of its cytoplasmic domain: the gamma subunit of Fc gamma RIIIA imparts phagocytic function to Fc gamma RI". Experimental Hematology 22 (7): 599–606. PMID 7516890.
Valerius T, Repp R, de Wit TP, Berthold S, Platzer E, Kalden JR, Gramatzki M, van de Winkel JG (Aug 1993). "Involvement of the high-affinity receptor for IgG (Fc gamma RI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy". Blood 82 (3): 931–9. PMID 7687898.
Wang AV, Scholl PR, Geha RS (Sep 1994). "Physical and functional association of the high affinity immunoglobulin G receptor (Fc gamma RI) with the kinases Hck and Lyn". The Journal of Experimental Medicine 180 (3): 1165–70. doi:10.1084/jem.180.3.1165. PMC 2191633. PMID 8064233.
Takai S, Kasama M, Yamada K, Kai N, Hirayama N, Namiki H, Taniyama T (Jan 1994). "Human high-affinity Fc gamma RI (CD64) gene mapped to chromosome 1q21.2-q21.3 by fluorescence in situ hybridization". Human Genetics 93 (1): 13–5. doi:10.1007/BF00218905. PMID 8270248.
Morton HC, van den Herik-Oudijk IE, Vossebeld P, Snijders A, Verhoeven AJ, Capel PJ, van de Winkel JG (Dec 1995). "Functional association between the human myeloid immunoglobulin A Fc receptor (CD89) and FcR gamma chain. Molecular basis for CD89/FcR gamma chain association". The Journal of Biological Chemistry 270 (50): 29781–7. doi:10.1074/jbc.270.50.29781. PMID 8530370.
De SK, Venkateshan CN, Seth P, Gajdusek DC, Gibbs CJ (Mar 1998). "Adenovirus-mediated human immunodeficiency virus-1 Nef expression in human monocytes/macrophages and effect of Nef on downmodulation of Fcgamma receptors and expression of monokines". Blood 91 (6): 2108–17. PMID 9490697.
Kyono WT, de Jong R, Park RK, Liu Y, Heisterkamp N, Groffen J, Durden DL (Nov 1998). "Differential interaction of Crkl with Cbl or C3G, Hef-1, and gamma subunit immunoreceptor tyrosine-based activation motif in signaling of myeloid high affinity Fc receptor for IgG (Fc gamma RI)". Journal of Immunology 161 (10): 5555–63. PMID 9820532.
Fanger NA, Cosman D, Peterson L, Braddy SC, Maliszewski CR, Borges L (Nov 1998). "The MHC class I binding proteins LIR-1 and LIR-2 inhibit Fc receptor-mediated signaling in monocytes". European Journal of Immunology 28 (11): 3423–34. doi:10.1002/(SICI)1521-4141(199811)28:11<3423::AID-IMMU3423>3.0.CO;2-2. PMID 9842885.
Gorgani NN, Altin JG, Parish CR (Aug 1999). "Histidine-rich glycoprotein regulates the binding of monomeric IgG and immune complexes to monocytes". International Immunology 11 (8): 1275–82. doi:10.1093/intimm/11.8.1275. PMID 10421785.
Tridandapani S, Lyden TW, Smith JL, Carter JE, Coggeshall KM, Anderson CL (Jul 2000). "The adapter protein LAT enhances fcgamma receptor-mediated signal transduction in myeloid cells". The Journal of Biological Chemistry 275 (27): 20480–7. doi:10.1074/jbc.M909462199. PMID 10781611.

Proteins: clusters of differentiation (see also list of human clusters of differentiation)

1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50

51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100

101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150

151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200

201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249

251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299

301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

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FCGR1A

Interactions

References

Further reading