FBXO4

F-box protein 4

Rendering based on PDB 3L2O.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols FBXO4 ; FBX4
External IDs OMIM: 609090 MGI: 2146220 HomoloGene: 8134 GeneCards: FBXO4 Gene
Orthologs
Species Human Mouse
Entrez 26272 106052
Ensembl ENSG00000151876 ENSMUSG00000022184
UniProt Q9UKT5 Q8CHQ0
RefSeq (mRNA) NM_001297437 NM_134099
RefSeq (protein) NP_001284366 NP_598860
Location (UCSC) Chr 5:
41.93 – 41.94 Mb
Chr 15:
3.97 – 3.98 Mb
PubMed search

F-box only protein 4 is a protein that in humans is encoded by the FBXO4 gene.[1][2][3]

Function

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants.[3]

Interactions

FBXO4 has been shown to interact with:

References

  1. 1 2 Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Dec 1999). "Identification of a family of human F-box proteins". Curr Biol 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.
  2. Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (Dec 1999). "A family of mammalian F-box proteins". Curr Biol 9 (20): 1180–2. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037.
  3. 1 2 "Entrez Gene: FBXO4 F-box protein 4".
  4. 1 2 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035.

Further reading


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