FAU (gene)

Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2L7R, 4V6X, 5AJ0

Identifiers

Symbols

FAU ; FAU1; Fub1; Fubi; MNSFbeta; RPS30; S30; asr1

External IDs

OMIM: 134690 MGI: 102547 HomoloGene: 37562 GeneCards: FAU Gene

Gene ontology
Molecular function	• RNA binding • structural constituent of ribosome • poly(A) RNA binding
Cellular component	• cellular_component • extracellular space • cytosol • small ribosomal subunit • cytosolic small ribosomal subunit
Biological process	• nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • innate immune response in mucosa • translation • translational initiation • translational elongation • translational termination • SRP-dependent cotranslational protein targeting to membrane • biological_process • gene expression • viral process • viral life cycle • viral transcription • antibacterial humoral response • cellular protein metabolic process • defense response to Gram-positive bacterium
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
65.12 – 65.12 Mb

Chr 19:
6.06 – 6.06 Mb

PubMed search

40S ribosomal protein S30 is a protein that in humans is encoded by the FAU gene.^[1]^[2]

Function

This gene is the cellular homolog of the fox sequence in the Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV). It encodes a fusion protein consisting of the ubiquitin-like protein fubi at the N-terminus and ribosomal protein S30 at the C-terminus. It has been proposed that the fusion protein is post-translationally processed to generate free fubi and free ribosomal protein S30. Fubi is a member of the ubiquitin family, and ribosomal protein S30 belongs to the S30E family of ribosomal proteins. Whereas the function of fubi is currently unknown, ribosomal protein S30 is a component of the 40S subunit of the cytoplasmic ribosome. Pseudogenes derived from this gene are present in the genome. Similar to ribosomal protein S30, ribosomal proteins S27a and L40 are synthesized as fusion proteins with ubiquitin.^[2]

References

↑ Kas K, Schoenmakers E, van de Ven W, Weber G, Nordenskjold M, Michiels L, Merregaert J, Larsson C (Oct 1993). "Assignment of the human FAU gene to a subregion of chromosome 11q13". Genomics 17 (2): 387–92. doi:10.1006/geno.1993.1337. PMID 8406491.
1 2 "Entrez Gene: FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived); ribosomal protein S30".

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Michiels L, Van der Rauwelaert E, Van Hasselt F; et al. (1993). "fau cDNA encodes a ubiquitin-like-S30 fusion protein and is expressed as an antisense sequence in the Finkel-Biskis-Reilly murine sarcoma virus". Oncogene 8 (9): 2537–46. PMID 8395683.
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Suzuki Y, Yamashita R, Shirota M; et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mourtada-Maarabouni M, Kirkham L, Farzaneh F, Williams GT (2005). "Regulation of apoptosis by fau revealed by functional expression cloning and antisense expression". Oncogene 23 (58): 9419–26. doi:10.1038/sj.onc.1208048. PMID 15543234.
Andersen JS, Lam YW, Leung AK; et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184.

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FAU (gene)

Function

References

Further reading