FANCF
| Fanconi anemia, complementation group F | |||||||||||||
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PDB rendering based on 2iqc. | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | FANCF ; FAF | ||||||||||||
| External IDs | OMIM: 613897 HomoloGene: 75185 GeneCards: FANCF Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
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| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 2188 | 100040608 | |||||||||||
| Ensembl | ENSG00000183161 | ENSMUSG00000092118 | |||||||||||
| UniProt | Q9NPI8 | E9Q5Z5 | |||||||||||
| RefSeq (mRNA) | NM_022725 | NM_001115087 | |||||||||||
| RefSeq (protein) | NP_073562 | NP_001108559 | |||||||||||
| Location (UCSC) |
Chr 11: 22.62 – 22.63 Mb |
Chr 7: 51.86 – 51.86 Mb | |||||||||||
| PubMed search | |||||||||||||
Fanconi anemia group F protein is a protein that in humans is encoded by the FANCF gene.[1][2]
Interactions
FANCF has been shown to interact with Fanconi anemia, complementation group C,[3][4] FANCG,[3][4][5][6] FANCA[3][4][7] and FANCE.[3][8]
References
- ↑ Joenje H, Oostra AB, Wijker M, di Summa FM, van Berkel CG, Rooimans MA, Ebell W, van Weel M, Pronk JC, Buchwald M, Arwert F (November 1997). "Evidence for at least eight Fanconi anemia genes". Am J Hum Genet 61 (4): 940–4. doi:10.1086/514881. PMC 1715980. PMID 9382107.
- ↑ "Entrez Gene: FANCF Fanconi anemia, complementation group F".
- 1 2 3 4 Léveillé, France; Blom Eric, Medhurst Annette L, Bier Patrick, Laghmani El Houari, Johnson Mark, Rooimans Martin A, Sobeck Alexandra, Waisfisz Quinten, Arwert Fré, Patel K J, Hoatlin Maureen E, Joenje Hans, de Winter Johan P (September 2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein". J. Biol. Chem. (United States) 279 (38): 39421–30. doi:10.1074/jbc.M407034200. ISSN 0021-9258. PMID 15262960. Cite uses deprecated parameter
|coauthors=(help) - 1 2 3 de Winter, J P; van der Weel L; de Groot J; Stone S; Waisfisz Q; Arwert F; Scheper R J; Kruyt F A; Hoatlin M E; Joenje H (November 2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Hum. Mol. Genet. (ENGLAND) 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. ISSN 0964-6906. PMID 11063725.
- ↑ Gordon, Susan M; Buchwald Manuel (July 2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems". Blood (United States) 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. ISSN 0006-4971. PMID 12649160.
- ↑ Medhurst, A L; Huber P A; Waisfisz Q; de Winter J P; Mathew C G (February 2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Hum. Mol. Genet. (England) 10 (4): 423–9. doi:10.1093/hmg/10.4.423. ISSN 0964-6906. PMID 11157805.
- ↑ Meetei, Amom Ruhikanta; de Winter Johan P, Medhurst Annette L, Wallisch Michael, Waisfisz Quinten, van de Vrugt Henri J, Oostra Anneke B, Yan Zhijiang, Ling Chen, Bishop Colin E, Hoatlin Maureen E, Joenje Hans, Wang Weidong (October 2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. (United States) 35 (2): 165–70. doi:10.1038/ng1241. ISSN 1061-4036. PMID 12973351. Cite uses deprecated parameter
|coauthors=(help) - ↑ Pace, Paul; Johnson Mark; Tan Wu Meng; Mosedale Georgina; Sng Chelvin; Hoatlin Maureen; de Winter Johan; Joenje Hans; Gergely Fanni; Patel K J (July 2002). "FANCE: the link between Fanconi anaemia complex assembly and activity". EMBO J. (England) 21 (13): 3414–23. doi:10.1093/emboj/cdf355. ISSN 0261-4189. PMC 125396. PMID 12093742.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- de Winter JP, Rooimans MA, van Der Weel L; et al. (2000). "The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM". Nat. Genet. 24 (1): 15–6. doi:10.1038/71626. PMID 10615118.
- de Winter JP, van der Weel L, de Groot J; et al. (2000). "The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG". Hum. Mol. Genet. 9 (18): 2665–74. doi:10.1093/hmg/9.18.2665. PMID 11063725.
- Medhurst AL, Huber PA, Waisfisz Q; et al. (2001). "Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway". Hum. Mol. Genet. 10 (4): 423–9. doi:10.1093/hmg/10.4.423. PMID 11157805.
- Pace P, Johnson M, Tan WM; et al. (2002). "FANCE: the link between Fanconi anaemia complex assembly and activity". EMBO J. 21 (13): 3414–23. doi:10.1093/emboj/cdf355. PMC 125396. PMID 12093742.
- Taniguchi T, D'Andrea AD (2002). "The Fanconi anemia protein, FANCE, promotes the nuclear accumulation of FANCC". Blood 100 (7): 2457–62. doi:10.1182/blood-2002-03-0860. PMID 12239156.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gordon SM, Buchwald M (2003). "Fanconi anemia protein complex: mapping protein interactions in the yeast 2- and 3-hybrid systems". Blood 102 (1): 136–41. doi:10.1182/blood-2002-11-3517. PMID 12649160.
- Meetei AR, Sechi S, Wallisch M; et al. (2003). "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome". Mol. Cell. Biol. 23 (10): 3417–26. doi:10.1128/MCB.23.10.3417-3426.2003. PMC 164758. PMID 12724401.
- Meetei AR, de Winter JP, Medhurst AL; et al. (2003). "A novel ubiquitin ligase is deficient in Fanconi anemia". Nat. Genet. 35 (2): 165–70. doi:10.1038/ng1241. PMID 12973351.
- Marsit CJ, Liu M, Nelson HH; et al. (2004). "Inactivation of the Fanconi anemia/BRCA pathway in lung and oral cancers: implications for treatment and survival". Oncogene 23 (4): 1000–4. doi:10.1038/sj.onc.1207256. PMID 14647419.
- Ota T, Suzuki Y, Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Tsutsumi S, Kamata N, Vokes TJ; et al. (2004). "The novel gene encoding a putative transmembrane protein is mutated in gnathodiaphyseal dysplasia (GDD)". Am. J. Hum. Genet. 74 (6): 1255–61. doi:10.1086/421527. PMC 1182089. PMID 15124103.
- Narayan G, Arias-Pulido H, Nandula SV; et al. (2004). "Promoter hypermethylation of FANCF: disruption of Fanconi Anemia-BRCA pathway in cervical cancer". Cancer Res. 64 (9): 2994–7. doi:10.1158/0008-5472.CAN-04-0245. PMID 15126331.
- Léveillé F, Blom E, Medhurst AL; et al. (2004). "The Fanconi anemia gene product FANCF is a flexible adaptor protein". J. Biol. Chem. 279 (38): 39421–30. doi:10.1074/jbc.M407034200. PMID 15262960.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Meetei AR, Levitus M, Xue Y; et al. (2004). "X-linked inheritance of Fanconi anemia complementation group B". Nat. Genet. 36 (11): 1219–24. doi:10.1038/ng1458. PMID 15502827.
- Meetei AR, Medhurst AL, Ling C; et al. (2005). "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M". Nat. Genet. 37 (9): 958–63. doi:10.1038/ng1626. PMC 2704909. PMID 16116422.
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