Etamiphylline

Etamiphylline
Names


IUPAC name 7-(2-diethylaminoethyl)-1,3-dimethylpurine-2,6-dione
Identifiers
CAS Number	314-35-2^Y
Jmol interactive 3D	Image
KEGG	D07378^Y
PubChem	28329
UNII	221A91BQ2S^Y
SMILES CCN(CC)CCN1C=NC2=C1C(=O)N(C(=O)N2C)C
Properties
Chemical formula	C₁₃H₂₁N₅O₂
Molar mass	279.33814
Pharmacology
ATC code	R03DA06
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is ^YN ?)
Infobox references

Etamiphylline (or etamiphyllin) is a xanthine intended for use as an anti-asthma agent. It has shown poor to absent effects in human clinical trials.^[1]^[2]

References

↑ Vazquez, C.; Labayru, T.; Rodriguez-Soriano, J. (1984). "Poor bronchodilator effect of oral etamiphylline in asthmatic children". Lancet 1 (8382): 914. doi:10.1016/s0140-6736(84)91380-1. PMID 6143224.
↑ Addis, G. J. (1984). "Absence of bronchodilatory effect from etamiphylline". Lancet 1 (8385): 1083. doi:10.1016/s0140-6736(84)91497-1. PMID 6144017.

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short-acting β₂ agonists	Bitolterol Carbuterol Fenoterol Pirbuterol Procaterol Reproterol Rimiterol Salbutamol (albuterol)^#/Levosalbutamol (levalbuterol) Terbutaline Tulobuterol

Long-acting β₂ agonists (LABA)	Bambuterol Clenbuterol Formoterol/Arformoterol Salmeterol Salmefamol

Ultra-long-acting β₂ agonists	Indacaterol Olodaterol Vilanterol

Other	Epinephrine^# Hexoprenaline Isoprenaline (isoproterenol) Orciprenaline (metaproterenol)

Glucocorticoids

Anticholinergics/
muscarinic antagonist

Mast cell stabilizers

Xanthines

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast

Arachidonate 5-lipoxygenase inhibitors	Baicalein^§ Caffeic acid^§ Curcumin^§ Hyperforin^§ Meclofenamate sodium^§ St John's wort^§ Zileuton

Thromboxane receptor antagonists	Ramatroban Seratrodast

Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast

Others/unknown

Combination products

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

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