Eric M. Genden

Eric M. Genden is an American otolaryngologist with the distinction of being the first surgeon to perform a jaw transplant in the United States.^[1] It was also the first jaw transplant ever to combine donor jaw with bone marrow from the patient.

Genden graduated Summa Cum Laude from Columbia College, Harvard University School of Public Health and graduated first in his medical school class at the Icahn School of Medicine at Mount Sinai. Genden's other achievements include the development of an advancement in tracheal transplants that allows patients to communicate and breathe normally.^[2]

Biography

Genden is the Isidore Friesner Professor and Chairman of Otolaryngology-Head and Neck Surgery and Professor of Neurosurgery, and Immunology at Icahn School of Medicine at Mount Sinai. He is Chairman of Otolaryngology-Head and Neck Surgery, Executive Vice President of Ambulatory Surgery, and Director of the Head and Neck Institute at the Mount Sinai Health System. His expertise is in thyroid, parathyroid surgery, head and neck cancer surgery, and airway reconstruction. Other titles include Professor (of both Otolaryngology-Head and Neck Surgery and Immunobiology) and Surgical Director of the Multidisciplinary Program for Head and Neck Cancer. He has been funded by the National Institutes of Health for his research in tracheal and laryngeal transplantation.

Memberships include the New York Head and Neck Society, American Head and Neck Society, American Board of Facial Plastic and Reconstructive Surgery, and the American Broncho-Esophagological Association. He received his B.A. degree from Columbia University in 1987 and graduated from Mount Sinai School of Medicine in 1992 where he obtained his MD degree with Distinction in Research, and Harvard University School of Public Health with a degree in Healthcare Management.

Jaw transplant

In 2006, Genden performed the first jaw transplant in North America,^[3] on a patient who carried the donated jaw in one of the back muscles for eight months. Along with several of his surgical team, Genden developed a technology using the patient's bone marrow and donor bony skeleton to create an immunological chimera. This technique has subsequently been applied to solid organ transplantation and Genden and his basic science team have been recognized by the National Academy of Science for this unique contribution to transplantation biology.

Tracheal transplant

In 2003, Genden performed the first reported tracheal transplantation that combined donor trachea cartilage with tissue from his patient. This innovation minimized the potential for rejection and, equally significantly, allowed the patient to communicate normally post-surgery. Genden has subsequently received international recognition for this work and has been nominated for the Marcus Prize in Medicine.

Awards, honors and recognition

• "Top Doctor" in Castle Connolly (2006, 2007, 2008, 2009, 2010, 2012, 2013, 2014)^[4]
• "Top Thyroid Doctor,"(2006, 2007, 2008, 2009, 2010) Thyroid-Info.com^[5]
• Best Clinical Innovations Award: The use of Osseointegrated Implants in Maxillary Reconstruction, Academy of Osseointegration, Boston, MA. 2003.
• American Academy of Otolaryngology-Head and Neck Surgery's Honor Award, 2003.
• Educator of the Year Award, Mount Sinai School of Medicine, Department of Otolaryngology-Head and Neck Surgery, 2003
• First Place, 2002 New York Academy of Sciences Resident Research Program Presentation
• 1998 Excellence in Teaching Award, Washington University in St. Louis
• Award for Outstanding Resident Research in Basic Science, 1997
• American Academy of Otolaryngic Allergy Award, 1996
• American Society for Peripheral Nerve Research Award, 1996
• Foundation Research Award, 1996.
• Hewlett-Packard Award for the Top Medical Graduate, 1992
• The Nathan A. Selz Prize for Outstanding Achievement in Research
• American Federation for Clinical Research Student Award, 1992
• Alpha Omega Alpha Honor Society June, 1992

Publications

Books

• Genden EM, Varvares M. Head and Neck Cancer: An Evidence-Based Team Approach. Thieme, New York, New York; First Edition, 2008 ISBN 1-58890-508-X
• Genden EM. Microvascular Free-Tissue Transfer: The Anatomy and Application of Free Flaps in Contemporary Head and Neck Reconstruction. American Academy of Otolaryngology - Head & Neck, 2006 ISBN 1-56772-098-6
• Genden EM. Contemporary Management of Head and Neck Tumors. Thieme, New York, New York; First Edition, in preparation.
• Urken ML, Buchbinder D, Okay D, Genden EM. Reconstruction of the Head and Neck: A Defect-Oriented Approach. Raven Press, New York, New York; First Edition, in preparation.

Other Publications (partial list)

• A rare prevertebral ordinary lipoma presenting as obstructive sleep apnea: computed tomographic and magnetic resonance imaging findings. Eloy JA, Carneiro E, Vibhute P, Genden EM, Bederson JB, Som PM. " Arch Otolaryngol Head Neck Surg. 2008 Sep. PMID 18794447
• Oral squamous cell carcinoma: histologic risk assessment, but not margin status, is strongly predictive of local diseasefree and overall survival. Brandwein-Gensler M, Teixeira MS, Lewis CM, Lee B, Rolnitzky L, Hille JJ, Genden E, Urken ML, Wang BY. Am J Surg Pathol. 2005 PMID 15644773
• Treatment considerations for head and neck cancer in the elderly. Genden EM, Rinaldo A, Shaha AR, Clayman GL, Werner JA, Suarez C, Ferlito A. J Laryngol Otol., 2005 PMID 15845185
• Reepithelialized orthotopic tracheal allografts expand memory cytotoxic T lymphocytes but show no evidence of chronic rejection. Cleven HA, Genden EM, Moran TM. Transplantation, 2005 PMID 12525206
• Is there a role for selective neck dissection after chemoradiation for head and neck cancer? Robbins KT, Ferlito A, Suarez C, Brizel DM, Bradley PJ, Pellitteri PK, Clayman GL, Kowalski LP, Genden EM, Rinaldo A. J Am Coll Surg., 2004 PMID 15555975
• Pharyngocutaneous fistula following laryngectomy. Genden EM, Rinaldo A, Shaha AR, Bradley PJ, Rhys-Evans PH, Ferlito A. Acta Otolaryngol., 2004 PMID 15072411
• Primary sphenoid sinus esthesioneuroblastoma. Morris L, Govindaraj S, Genden EM. Am J Otolaryngol., 2004 PMID 15334400
• Complications of free flap transfers for head and neck reconstruction following cancer resection. Genden EM, Rinaldo A, Suarez C, Wei WI, Bradley PJ, Ferlito A. Oral Oncol., 2004 PMID 15509488
• Effect of fibrin matrix and vascular endothelial growth factor on reepithelialization of orthotopic murine tracheal transplants. Govindaraj S, Gordon R, Genden EM. Ann Otol Rhinol Laryngol., 2004 PMID 15535142
• Reconstruction of the hard palate with the radial forearm free flap: Outcomes and Quality of Life. Wallace D, Genden EM, Urken ML. Head and Neck, 2004 PMID 15350027
• Sensory topography of the oral cavity and the impact of free flap reconstruction: A preliminary study. Zur KB, Genden EM, Urken ML. Head and Neck, 2004 PMID 15390196
• Prediction of Postoperative Hypocalcemia after Thyroid Surgery using a Rapid Intraoperative Parathyroid Hormone Assay. Mandell DL, Genden EM, Mechanick JI, Bergman DA, Urken ML. Arch Otolaryngol Head Neck Surg., 2004

References

External links

• Mount Sinai Hospital homepage
• Icahn School of Medicine at Mount Sinai
• Medical News Today: Fighting Cancer Using A Multidisciplinary Approach
• American Head & Neck Society
• New York Head & Neck Society