Epigen

Epithelial mitogen

Identifiers

EPGN ; ALGV3072; EPG; PRO9904

External IDs

HomoloGene: 19527 GeneCards: EPGN Gene

Gene ontology
Molecular function	• epidermal growth factor receptor binding • growth factor activity
Cellular component	• extracellular space • intracellular • integral component of plasma membrane
Biological process	• MAPK cascade • activation of MAPK activity • angiogenesis • epidermal growth factor receptor signaling pathway • positive regulation of cell proliferation • positive regulation of MAP kinase activity • positive regulation of epidermal growth factor-activated receptor activity • positive regulation of mitotic nuclear division • positive regulation of epithelial cell proliferation
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 4:
74.31 – 74.32 Mb

Chr 5:
91.03 – 91.04 Mb

PubMed search

Epigen also known as epithelial mitogen is a protein that in humans is encoded by the EPGN gene.^[1]^[2]

Function

The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate.^[1]

References

1 2 "Entrez Gene: Epithelial mitogen".
↑ Schneider MR, Yarden Y (2014). "Structure and function of epigen, the last EGFR ligand". Semin. Cell Dev. Biol. 28: 57–61. doi:10.1016/j.semcdb.2013.12.011. PMC 4037347. PMID 24374012.

External links

epigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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