Endothelin converting enzyme 1

Human ECE-1 complexed with phosphoramidon. PDB 3dwb

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
3DWB

Identifiers

Symbols

ECE1 ; ECE

External IDs

OMIM: 600423 MGI: 1101357 HomoloGene: 1068 ChEMBL: 4791 GeneCards: ECE1 Gene

EC number

3.4.24.71

Gene ontology
Molecular function	• endopeptidase activity • metalloendopeptidase activity • protein binding • peptide hormone binding • protein homodimerization activity • metal ion binding
Cellular component	• lysosomal membrane • endosome • early endosome • plasma membrane • external side of plasma membrane • membrane • integral component of membrane • intrinsic component of endosome membrane • vesicle • Weibel-Palade body • perinuclear region of cytoplasm • extracellular exosome
Biological process	• positive regulation of receptor recycling • regulation of systemic arterial blood pressure by endothelin • heart development • substance P catabolic process • bradykinin catabolic process • calcitonin catabolic process • protein processing • peptide hormone processing • regulation of vasoconstriction • endothelin maturation • hormone catabolic process • embryonic digit morphogenesis • ear development • pharyngeal system development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
21.22 – 21.35 Mb

Chr 4:
137.86 – 137.97 Mb

PubMed search

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.^[1]^[2]^[3]

Function

Endothelin-converting enzyme-1 is involved in the proteolytic processing of endothelin-1 (EDN1), -2 (EDN2), and -3 (EDN3) to biologically active peptides.^[1]

References

1 2 "Entrez Gene: ECE1 endothelin converting enzyme 1".
↑ Schmidt M, Kröger B, Jacob E, Seulberger H, Subkowski T, Otter R, Meyer T, Schmalzing G, Hillen H (December 1994). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.
↑ Shimada K, Matsushita Y, Wakabayashi K, Takahashi M, Matsubara A, Iijima Y, Tanzawa K (February 1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876.

Yorimitsu K, Moroi K, Inagaki N; et al. (1995). "Cloning and sequencing of a human endothelin converting enzyme in renal adenocarcinoma (ACHN) cells producing endothelin-2". Biochem. Biophys. Res. Commun. 208 (2): 721–7. doi:10.1006/bbrc.1995.1397. PMID 7695628.
Schmidt M, Kröger B, Jacob E; et al. (1995). "Molecular characterization of human and bovine endothelin converting enzyme (ECE-1)". FEBS Lett. 356 (2–3): 238–43. doi:10.1016/0014-5793(94)01277-6. PMID 7805846.
Shimada K, Matsushita Y, Wakabayashi K; et al. (1995). "Cloning and functional expression of human endothelin-converting enzyme cDNA". Biochem. Biophys. Res. Commun. 207 (2): 807–12. doi:10.1006/bbrc.1995.1258. PMID 7864876.
Valdenaire O, Rohrbacher E, Mattei MG (1996). "Organization of the gene encoding the human endothelin-converting enzyme (ECE-1)". J. Biol. Chem. 270 (50): 29794–8. doi:10.1074/jbc.270.50.29794. PMID 8530372.
Matsuoka R, Sawamura T, Yamada K; et al. (1996). "Human endothelin converting enzyme gene (ECE1) mapped to chromosomal region 1p36.1". Cytogenet. Cell Genet. 72 (4): 322–4. doi:10.1159/000134214. PMID 8641140.
Orzechowski HD, Richter CM, Funke-Kaiser H; et al. (1997). "Evidence of alternative promoters directing isoform-specific expression of human endothelin-converting enzyme-1 mRNA in cultured endothelial cells". J. Mol. Med. 75 (7): 512–21. doi:10.1007/s001090050136. PMID 9253714.
Schweizer A, Valdenaire O, Nelböck P; et al. (1998). "Human endothelin-converting enzyme (ECE-1): three isoforms with distinct subcellular localizations". Biochem. J. 328 ( Pt 3) (Pt 3): 871–7. PMC 1218999. PMID 9396733.
Kido T, Sawamura T, Masaki T (1998). "The processing pathway of endothelin-1 production". J. Cardiovasc. Pharmacol. 31 Suppl 1: S13–5. doi:10.1097/00005344-199800001-00006. PMID 9595387.
Hofstra RM, Valdenaire O, Arch E; et al. (1999). "A loss-of-function mutation in the endothelin-converting enzyme 1 (ECE-1) associated with Hirschsprung disease, cardiac defects, and autonomic dysfunction". Am. J. Hum. Genet. 64 (1): 304–8. doi:10.1086/302184. PMC 1377732. PMID 9915973.
Lee S, Lin M, Mele A; et al. (1999). "Proteolytic processing of big endothelin-3 by the kell blood group protein". Blood 94 (4): 1440–50. PMID 10438732.
Valdenaire O, Lepailleur-Enouf D, Egidy G; et al. (1999). "A fourth isoform of endothelin-converting enzyme (ECE-1) is generated from an additional promoter molecular cloning and characterization". Eur. J. Biochem. 264 (2): 341–9. doi:10.1046/j.1432-1327.1999.00602.x. PMID 10491078.
Fahnoe DC, Johnson GD, Herman SB, Ahn K (2000). "Disulfide bonds in big ET-1 are essential for the specific cleavage at the Trp(21)-Val(22) bond by soluble endothelin converting enzyme-1 from baculovirus/insect cells". Arch. Biochem. Biophys. 373 (2): 385–93. doi:10.1006/abbi.1999.1586. PMID 10620363.
López-Ongil S, Senchak V, Saura M; et al. (2000). "Superoxide regulation of endothelin-converting enzyme". J. Biol. Chem. 275 (34): 26423–7. doi:10.1074/jbc.M000767200. PMID 10833511.
Hachiya A, Kobayashi T, Takema Y, Imokawa G (2002). "Biochemical characterization of endothelin-converting enzyme-1alpha in cultured skin-derived cells and its postulated role in the stimulation of melanogenesis in human epidermis". J. Biol. Chem. 277 (7): 5395–403. doi:10.1074/jbc.M105874200. PMID 11723113.
Inguimbert N, Coric P, Poras H; et al. (2002). "Toward an optimal joint recognition of the S1' subsites of endothelin converting enzyme-1 (ECE-1), angiotensin converting enzyme (ACE), and neutral endopeptidase (NEP)". J. Med. Chem. 45 (7): 1477–86. doi:10.1021/jm0005454. PMID 11906289.
MacLeod KJ, Husain RD, Gage DA, Ahn K (2003). "Constitutive phosphorylation of human endothelin-converting enzyme-1 isoforms". J. Biol. Chem. 277 (48): 46355–63. doi:10.1074/jbc.M207972200. PMID 12244060.
Muller L, Barret A, Etienne E; et al. (2003). "Heterodimerization of endothelin-converting enzyme-1 isoforms regulates the subcellular distribution of this metalloprotease". J. Biol. Chem. 278 (1): 545–55. doi:10.1074/jbc.M208949200. PMID 12393864.
Eckman EA, Watson M, Marlow L; et al. (2003). "Alzheimer's disease beta-amyloid peptide is increased in mice deficient in endothelin-converting enzyme". J. Biol. Chem. 278 (4): 2081–4. doi:10.1074/jbc.C200642200. PMID 12464614.
Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Masatsugu K, Itoh H, Chun TH; et al. (2003). "Shear stress attenuates endothelin and endothelin-converting enzyme expression through oxidative stress". Regul. Pept. 111 (1–3): 13–9. doi:10.1016/S0167-0115(02)00219-7. PMID 12609744.
Smollich M, Götte M, Yip GW; et al. (2007). "On the role of endothelin-converting enzyme 1 (ECE-1) and neprilysin in human breast cancer". Breast Cancer Res. Treat. 106 (3): 361–9. doi:10.1007/s10549-007-9516-9. PMID 17295044.

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Endothelin converting enzyme 1

Function

References

Further reading